1004-75-7Relevant articles and documents
Synthesis of 7-methyl-6-indolopterin and 7-methyl-6-indoloquinoxaline
Goswami, Shyamaprosad,Das, Manas Kumar,Maity, Annada C.,Quah, Ching Kheng,Fun, Hoong-Kun
, p. 1529 - 1536 (2016)
The first syntheses of indolopterin and indoloquinoxaline, two important and dissimilar diheterocycles linking C-2 of indole with C-6 of pterin (significant positions for showing biological activity), and quinoxaline, respectively, have been achieved base
PREPARATION OF 5-AMINO-7(6H)-FURAZANOPYRIMIDINONE AN ANALOG OF PTERIN
Boyle, Peter H.,Lockhart, Ronan J.
, p. 879 - 886 (1984)
5-Aminofurazanopyrimidines carrying a variety of substituents at position 7 suffer ring cleavage by either acid or base to give 4-guanidino-3-furazancarboxylic acid (6), the esters of which can be recyclised to give the pterin analog 5-amino-7(6H)-
2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate, 2-amino, 2-cyanoacetic acid and synthesis process thereof
-
Paragraph 0028; 0034-0036, (2021/09/21)
The invention discloses a synthesis process of 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate. The synthesis process comprises the following step: carrying out pressurized catalytic hydrogenation reaction on liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate to generate the 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate. Wherein the liquid 2-nitroso and 2-methyl cyanoacetate/ethyl cyanoacetate are generated by carrying out nitrosation reaction on methyl cyanoacetate/ethyl cyanoacetate and sodium nitrite. The 2-amino, 2-methyl cyanoacetate/ethyl cyanoacetate can be used as an intermediate in the synthesis process of 2, 4, 5-triamino-6-hydroxypyrimidine, and can be directly subjected to ring closing with guanidyl to generate 2, 4, 5-triamino-6-hydroxypyrimidine, so that the problems of high water consumption and high wastewater yield in the synthesis process can be solved, and great economic significance and environmental protection significance are achieved. In addition, the invention further develops the application of the intermediate, and the intermediate can be used for synthesizing 2, 4, 5-triamino-6-hydroxypyrimidine and guanidyl to generate 2, 4, 5-triamino-6-hydroxypyrimidine, and can also be used for synthesizing 2-amino and 2-cyanoacetic acid.
Triaminopyrimimelamino 2, 4, 5- pyrimidine formate -6- and preparation method and application thereof
-
Paragraph 0055-0058; 0067-0070, (2019/11/29)
The invention discloses 2,4,5-triamido-6-hydroxy pyrimidine formate and a preparation method. The preparation method comprises the following steps: enabling 2,4-diamido-5-nitro-6-hydroxy pyrimidine toreact with hydrogen in catalyst A and alkaline solution B, and obtaining 2,4,5-triamido-6-hydroxyl pyrimidine; and enabling a hydrogenation product to perform the salt forming reaction with formic acid to obtain 2,4,5-triamido-6-hydroxy pyrimidine formate. The invention discloses a method for preparing guanine by utilizing the 2,4,5-triamido-6-hydroxy pyrimidine formate. The preparation method isshort in production route, and high in molar yield, wherein the total molar yield is 90 percent or higher. The solvent can be recycled and generally used, the content of the salt and strong acid in the production wastewater can be greatly reduced, and the emission amount is little. The pyrimidine formate is a brand new compound. The pyrimidine formate is used for substituting the pyrimidine sulfate to prepare the guanine, so that a great amount of sulfate can be prevented from flowing into the production wastewater.
