100644-00-6 Usage
Molecular structure
A complex structure containing three methyl groups, a tetrahydropyridazin-3-yl group, and an indol-2-one group.
Chemical class
Belongs to the indolone class of compounds.
Potential applications
Has potential applications in pharmaceutical and medicinal chemistry due to its unique structure and potential biological activities.
Further research needed
More research and studies are required to fully understand its properties and potential uses.
Biological activities
The specific biological activities of this compound are not mentioned in the provided material, but its unique structure suggests it may have potential in this area.
Stability
The stability of this compound is not mentioned in the provided material, but it is generally important to consider the stability of complex chemical compounds in pharmaceutical and medicinal applications.
Solubility
The solubility of this compound is not mentioned in the provided material, but it is an important factor to consider for its potential use in drug development.
Synthesis
The synthesis method for this compound is not provided in the material, but it is an important aspect to consider for its potential production and use.
Safety and toxicity
The safety and toxicity of this compound are not mentioned in the provided material, but these are important factors to consider for its potential use in pharmaceutical and medicinal applications.
Check Digit Verification of cas no
The CAS Registry Mumber 100644-00-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,6,4 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100644-00:
(8*1)+(7*0)+(6*0)+(5*6)+(4*4)+(3*4)+(2*0)+(1*0)=66
66 % 10 = 6
So 100644-00-6 is a valid CAS Registry Number.
100644-00-6Relevant articles and documents
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites
Robertson,Krushinski,Utterback,Kauffman
, p. 1476 - 1480 (1989)
We have radiolabeled a structural analogue of indolidan, a potent phosphodiesterase-inhibitor cardiotonic, to permit biochemical studies regarding the interaction of this class of drugs with their pharmacological receptor. [3H]-LY186126 (1,3-dihydro-3,3-dimethyl-1-[3H3]methyl-5-(1,4,5,6-tetrahydro-4-metht yl-6-oxo-3-pyridazinyl)-2H-indol-2-one; [3H]-3) was selected as a synthetic target because of its potency as a cardiotonic and the ability to readily incorporate three tritia via the indolone N-CH3 substituent. Alkylation of a desmethyl precursor with tritium-labeled iodomethane resulted in [3H]-3 with a radiochemical purity of 98% and a specific activity of 79.2 Ci/mmol. This radioligand binds with high affinity to myocardial membrane vesicles. The binding was saturable, and K(d) and B(max) values of 4.1 nM and 383 fmol/mg protein were obtained. A series of indolidan congeners displaced [3H]-3 bound to myocardial vesicles, and K(i) values for inhibition of binding were highly correlated with canine inotropic ED50 values, suggesting the specific binding of [3H]-3 to cardiac vesicles is pharmacologically relevant.
Dihydropyridazinone cardiotonics: The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyrid azinyl)-2H-indol-2-one
Robertson,Krushinski,Beedle,Wyss,Pollock,Wilson,Kauffman,Hayes
, p. 1832 - 1840 (2007/10/02)
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