100701-49-3Relevant articles and documents
ENANTIOSELECTIVE SYNTHESIS OF MONOFLUORINATED MALONIC ACID MONOESTERS WITH ENZYMES OF MICROBAL ORIGIN
Kitazume, Tomoya,Sato, Takehiko,Ishikawa, Nobuo
, p. 1811 - 1814 (1984)
The optically active (+)- and (-)-2-fluoro-2-substituted malonic acid monoesters useful as the practical chiral synthon were obtained by the microbial hydrolysis of the corresponding malonic acid diesters with esterases or cellulases.
A novel class of ion displacement ligands as antagonists of the αiIbβ3 receptor that limit conformational reorganization of the receptor
Jiang, Jian-Kang,McCoy, Joshua G.,Shen, Min,LeClair, Christopher A.,Huang, Wenwei,Negri, Ana,Li, Jihong,Blue, Robert,Harrington, Amanda Weil,Naini, Sarasija,David III, George,Choi, Won-Seok,Volpi, Elisabetta,Fernandez, Joseph,Babayeva, Mariana,Nedelman, Mark A.,Filizola, Marta,Coller, Barry S.,Thomas, Craig J.
supporting information, p. 1148 - 1153 (2014/03/21)
A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic
AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE
-
Paragraph 0117, (2014/01/08)
[Problems to be Solved by the Invention] To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety. [Means for Solving the Problems] A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom m represents an integer 0, 1, or 2, n represents an integer 0 or 1 Ar1 represents a bicyclic heterocyclic group represented by the following formula: wherein Aa represents a nitrogen atom or C-Ra, Ab represents a nitrogen atom or C-Rb, and Ac represents a nitrogen atom or C-Rc, Ra, Rb, and Rc independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, R1 and R2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group, Ar2 represents a bicyclic heterocyclic group represented by the following formulae: