101077-32-1Relevant articles and documents
POTENTIAL ANTIDEPRESSANTS AND TRANQUILLIZERS: SYNTHESIS OF SOME 9-(AMINOALKOXY)-2,3,6,7-TETRAHYDRO-1H,5H-BENZO QUINOLIZINES AND 1-(SUBSTITUTED AMINO)-3-(1-NAPHTHOXY)-2-PROPANOLS
Vejdelek, Zdenek,Protiva, Miroslav
, p. 1290 - 1296 (2007/10/02)
The hydrobromide of 9-hydroxyjulolidine was reacted with hydrochloride of 2-dimethylaminoethyl chloride, 2-(1-pyrrolidinyl)ethyl chloride, 2-(1-piperidinyl)ethyl chloride, and 3-dimethylaminopropyl chloride in ethanol in the presence of sodium ethoxide to give the title bases II - V which were transformed to dihydrochlorides.Heating of 1,2-epoxy-3-(1-naphthoxy)propane with 2,3,3-trimethyl-2-butylamine, 1-methylcyclopentylamine, 1-methylcyclohexylamine, 1-methylcycloheptylamine, and 10,11-dihydrodibenzocycloheptene-5-amine in ethanol afforded the second part of the title compounds (VII - XI), prepared also in the form of hydrochlorides.Only the ethers II and V showed indications of possible antidepressant activity.