101273-81-8 Usage
Description
2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE is a chemical compound with the molecular formula C16H11NO2, belonging to the isoquinoline family. It is recognized for its biological activities, such as antioxidant, anti-inflammatory, and anticancer properties, and is utilized as an intermediate in the synthesis of various biologically active compounds, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE is used as an intermediate in the synthesis of pharmaceuticals for its potential to treat various diseases and conditions. Its biological activities, including antioxidant, anti-inflammatory, and anticancer properties, make it a valuable component in the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE serves as a key building block for the creation of complex organic molecules. Its unique structure and functional groups allow for versatile chemical reactions, contributing to the advancement of organic chemistry.
Used in Anticancer Applications:
2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE is used as a potential anticancer agent, given its biological activities that may help in the treatment of various types of cancer. Its antioxidant and anti-inflammatory properties could also contribute to the mitigation of cancer-related inflammation and oxidative stress.
Used in Neurodegenerative Disorder Treatment:
Due to its potential neuroprotective effects, 2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE is considered for use in the treatment of neurodegenerative disorders. Its antioxidant properties may help combat the oxidative stress associated with such conditions, potentially slowing their progression.
Used in Inflammatory Disease Management:
2-O-TOLYL-4H-ISOQUINOLINE-1,3-DIONE is used in the management of inflammatory diseases due to its anti-inflammatory properties. It may help reduce inflammation and associated symptoms, providing relief and potentially aiding in the treatment of these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 101273-81-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,2,7 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 101273-81:
(8*1)+(7*0)+(6*1)+(5*2)+(4*7)+(3*3)+(2*8)+(1*1)=78
78 % 10 = 8
So 101273-81-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO2/c1-11-6-2-5-9-14(11)17-15(18)10-12-7-3-4-8-13(12)16(17)19/h2-9H,10H2,1H3
101273-81-8Relevant articles and documents
Superelectrophiles in Synthesis: Preparation of Aromatic Imides
Kennedy, Sean H.,Schaeff, Mark N.,Klumpp, Douglas A.
, p. 14133 - 14140 (2019/10/16)
Aromatic carboxylic acids are found to undergo reactions with isocyanates, wherein triflic acid promotes the formation of aromatic imide products in fair to good yields. It is proposed that the carboxylic acid group directs the isocyanate electrophile to
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: Identification of the target molecule and a structure-activity relationship study
Komoda, Masato,Kakuta, Hiroki,Takahashi, Hiroyasu,Fujimoto, Yasuyuki,Kadoya, Shizuo,Kato, Fuminori,Hashimoto, Yuichi
, p. 121 - 131 (2007/10/03)
2-(2,6-Diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (2: PIQ-22) was found to be a potent and specific inhibitor of puromycin-sensitive aminopeptidase (PSA). Lineweaver-Burk plot analysis showed that PSA is inhibited by PIQ-22 in a non-competitive manner. Structure-activity relationship studies indicated that tautomerism of the imidobenzoylketone group in the cyclic imide moiety of the PIQ-22 skeleton is important for the inhibitory activity.