101337-92-2Relevant articles and documents
Synthesis and antifungal activity against strains of Candida albicans of 6-fluoro-4(5 or 7)-chloro-2-(difluorobenzoyl)aminobenzothiazoles
Armenise, Domenico,De Laurentis, Nicolino,Reho, Antonia,Rosato, Antonio,Morlacchi, Flaviano
, p. 771 - 775 (2004)
A series of 6-fluoro-4-(5 or 7)-chloro-2-(difluorobenzoyl) aminobenzothiazoles 3a-r were prepared to investigate their potential biological activity. In this work, the results of their in vitro antifungal activity against some strains of Candida albicans
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives
Srivastava, Pavan,Vyas, Vivek K.,Variya, Bhavesh,Patel, Palak,Qureshi, Gulamnizami,Ghate, Manjunath
supporting information, p. 130 - 138 (2016/07/11)
In the present study, 7-subsituted coumarin derivatives were synthesized using various aromatic and heterocyclic amines, and evaluated in vivo for anti-inflammatory and analgesic activity, and for ulcerogenic risk. The most active compounds were evaluated in vitro for 5-lipoxygenase (5-LOX) inhibition. Docking study was performed to predict the binding affinity, and orientation at the active site of the enzyme. In vivo anti-inflammatory and analgesic activity, and in vitro 5-LOX enzyme inhibition study revealed that compound 33 and 35 are the most potent compounds in all the screening methods. In vitro kinetic study of 35 showed mixed or non-competitive type of inhibition with 5-LOX enzyme. Presence of [Formula presented]3 group in 35 and [Formula presented] in 33 at C6-position of benzothiazole ring were found very important substitutions for potent activity.
Synthesis and biological activity of 2-amino-4H-pyrimido[2,1-b][1,3] benzothiazole-3-carboxylates
Chaithanya,Vaidya,Nagendrappa
experimental part, p. 1618 - 1620 (2012/01/05)
3-Chloro-4-fluoro aniline (1) on reaction with potassium thiocyanate (2) followed by the addition of bromine in acetic acid medium yielded 2-amino 5-chloro-6-fluro[2,1-b][1,3]benzothiazole (3). Compound 3 when treated with β-cyanoester undergoes cycloaddi