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10173-67-8

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10173-67-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 10173-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,7 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10173-67:
(7*1)+(6*0)+(5*1)+(4*7)+(3*3)+(2*6)+(1*7)=68
68 % 10 = 8
So 10173-67-8 is a valid CAS Registry Number.

10173-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-2-(2-fluorobenzimidazolo[1,2-c]quinazolin-6-yl)aniline

1.2 Other means of identification

Product number -
Other names 4-fluoro-2-(2-fluoro-benzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-aniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10173-67-8 SDS

10173-67-8Downstream Products

10173-67-8Relevant articles and documents

Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives

Li, Jun-cai,Wang, Ren-xuan,Sun, Yu,Zhu, Jia-kai,Hu, Guan-fang,Wang, Yu-ling,Zhou, Rui,Zhao, Zhong-min,Liu, Ying-qian,Peng, Jing-wen,Yan, Yin-fang,Shang, Xiao-fei

, (2019)

In this paper, the nitrogen atom was inserted into the anthracycline system of the isocryptolepine nucleus to obtain the “Aza”-type structure benzo[4,5]imidazo[1,2-c] quinazoline. A series of “Aza”-type derivatives were designed, synthesized and evaluated for their antifungal activity against six plant fungi in vitro. Among all derivatives, compounds A-0, B-1 and B-2 showed significant antifungal activity against B. cinerea with the EC50 values of 2.72 μg/mL, 5.90 μg/mL and 4.00 μg/mL, respectively. Compound A-2 had the highest activity against M. oryzae with the EC50 values of 8.81 μg/mL, and compound A-1 demonstrated the most control efficacy against R. solani (EC50, 6.27 μg/mL). Moreover, compound A-0 was selected to investigate the in vivo tests against B. cinerea and the results indicated that the preventative efficacy of it up to 72.80% at 100 μg/mL. Preliminary mechanism studies revealed that after treatment with A-0 at 5 μg/mL, the B. cinerea mycelia appeared curved, collapsed and the cell membrane integrity may be damaged. The reactive oxygen species production, mitochondrial membrane potential and nuclear morphometry of mycelia have been changed, and the membrane function and cell proliferation of mycelia were destroyed. Compounds A-0, A-1, B-1 and B-2 presented weaker toxicities against two cells lines than isocryptolepine. This study lays the foundation for the future development of isocryptolepine derivatives as environmentally friendly and safe agricultural fungicides.

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