102153-63-9 Usage
Description
6-Chloro-2-naphthylsulfonyl chloride is a sulfonyl chloride derivative of 6-chloro-2-naphthol, a chemical compound that serves as a reagent in organic synthesis. It is renowned for its selective modification capabilities of other organic compounds, offering a high degree of reactivity and specificity, which makes it an indispensable tool for researchers and chemists in the synthesis of novel organic compounds.
Uses
Used in Organic Synthesis:
6-Chloro-2-naphthylsulfonyl chloride is used as a sulfonylating agent for the introduction of the 6-chloro-2-naphthylsulfonyl group into various organic molecules. Its application is crucial in selectively modifying the structures of these compounds, which is vital for the advancement of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Chloro-2-naphthylsulfonyl chloride is utilized as a key intermediate in the synthesis of certain pharmaceutical compounds. Its ability to selectively modify organic molecules contributes to the development of new drugs with improved therapeutic properties.
Used in Chemical Research:
6-Chloro-2-naphthylsulfonyl chloride is employed as a research tool in chemical laboratories for studying the reactivity and selectivity of sulfonyl chlorides in various chemical reactions. This helps in understanding the underlying mechanisms and contributes to the discovery of new reaction pathways and methodologies.
Used in Material Science:
In the field of material science, 6-Chloro-2-naphthylsulfonyl chloride is used for the functionalization of polymers and other materials. Its sulfonylating properties allow for the attachment of specific functional groups, which can enhance the properties of the materials for various applications, such as sensors, catalysts, and advanced materials.
Used in Agrochemical Industry:
6-Chloro-2-naphthylsulfonyl chloride is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and herbicides. Its ability to modify organic molecules can lead to the development of more effective and targeted agrochemicals with reduced environmental impact.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 6-Chloro-2-naphthylsulfonyl chloride is employed for the synthesis of novel dyes and pigments with improved colorfastness and stability. Its sulfonylating properties enable the attachment of specific functional groups, which can enhance the performance of these colorants in various applications, such as textiles, plastics, and inks.
Check Digit Verification of cas no
The CAS Registry Mumber 102153-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,1,5 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 102153-63:
(8*1)+(7*0)+(6*2)+(5*1)+(4*5)+(3*3)+(2*6)+(1*3)=69
69 % 10 = 9
So 102153-63-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H6Cl2O2S/c11-9-3-1-8-6-10(15(12,13)14)4-2-7(8)5-9/h1-6H
102153-63-9Relevant articles and documents
Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors
Imaeda, Yasuhiro,Miyawaki, Toshio,Sakamoto, Hiroki,Itoh, Fumio,Konishi, Noriko,Hiroe, Katsuhiko,Kawamura, Masaki,Tanaka, Toshimasa,Kubo, Keiji
, p. 2243 - 2260 (2008/12/20)
Factor Xa (FXa) is a trypsin-like serine protease involved in the coagulation cascade and has received great interest as a potential target for the development of new antithrombotic agents. Most of amidine-type FXa inhibitors reported have been found to s
Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element
Haginoya, Noriyasu,Kobayashi, Syozo,Komoriya, Satoshi,Yoshino, Toshiharu,Suzuki, Makoto,Shimada, Takashi,Watanabe, Kengo,Hirokawa, Yumiko,Furugori, Taketoshi,Nagahara, Takayasu
, p. 5167 - 5182 (2007/10/03)
Our exploratory study was based on the concept that a non-amidine factor Xa (fXa) inhibitor is suitable for an orally available anticoagulant. We synthesized and evaluated a series of N-(6-chloronaphthalen-2-yl) sulfonylpiperazine derivatives incorporating various fused-bicyclic rings containing an aliphatic amine expected to be S4 binding element. Among this series, 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine type 61 displayed orally potent anti-fXa activity and evident prolongation of prothrombin time (PT) with the moderate bioavailability in rats. The X-ray crystal analysis afforded an obvious binding mode that 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c] pyridine and 6-chloronaphthalene respectively bound to S4 and S1 subsites. In this X-ray study, we discovered a novel intramolecular S-O close contact. Ab initio energy calculations of model compounds deduced that conformers with the most close S-O proximity were most stable. The Mulliken population analysis proposed that this energy profile was caused by both of electrostatic S-O affinity and N-O repulsion. The results of these calculations and X-ray analysis suggested a possibility that the restricted conformation effected the affinity to S4 subsite of fXa.
Substituted heterocyclic amides
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, (2008/06/13)
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermedia
