103322-70-9 Usage
Class
Heterocyclic compound
Structure
Contains a thiazole and pyrimidine ring system
Use
Synthetic intermediate in the preparation of pharmaceutical compounds
Pharmacological Activities
Potential as an antiviral and anticancer agent, studied for treating neurodegenerative disorders
Importance
Versatile and valuable compound for medicinal chemistry research and drug development
Check Digit Verification of cas no
The CAS Registry Mumber 103322-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,3,2 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 103322-70:
(8*1)+(7*0)+(6*3)+(5*3)+(4*2)+(3*2)+(2*7)+(1*0)=69
69 % 10 = 9
So 103322-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N5OS/c6-4-9-2(11)1-3(10-4)12-5(7)8-1/h(H2,7,8)(H3,6,9,10,11)
103322-70-9Relevant articles and documents
Inhibitors of Human Purine Nucleoside Phosphorylase. Synthesis, Purine Nucleoside Phosphorylase Inhibition, and T-Cell Cytotoxicity of 2,5-Diaminothiazolopyrimidin-7(6H)-one and 2,5-Diaminothiazolopyrimidin-7-(6H)-one. Two Thio Isosteres of 8-Aminoguanine.
Sircar, Jagadish C.,Suto, Mark J.,Scott, Mary E.,Dong, Mi K.,Gilbertsen, Richard B.
, p. 1804 - 1806 (1986)
8-Aminoguanine is a potent inhibitor of purine nucleoside phosphorylase (PNP) and also a substrate of PNP.Two thioisosteres of 8-aminoguanine, 2,5-diaminothiazolopyrimidin-7(6H)-one (2) and 2,4-diaminothiazolopyrimidin-7(6H)-one (3), which cannot be substrates of PNP, were synthesized and evaluated for their inhibitory activity against PNP.They were found to be weak inhibitors of PNP and to be noncytotoxic for MOLT-4 T-cells in culture.
