103674-69-7Relevant articles and documents
Quinoline compound containing sulfonamide structure as well as preparation method and medical application thereof
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Paragraph 0033; 0040; 0042, (2021/07/01)
The invention belongs to the technical field of medicines, and relates to a quinoline compound containing a sulfonamide structure as well as a preparation method and medical application of the quinoline compound. The quinoline compound containing the sulf
Synthesis of glucuronic acid derivatives via the efficient and selective removal of a C6 methyl group
Hou, Zhuang,Liu, Yang,Zhang, Xin-xin,Chang, Xiao-wei,Cheng, Mao-sheng,Guo, Chun
supporting information, p. 423 - 426 (2017/01/10)
This investigation is related to the development of a general strategy for the synthesis of certain glucuronic acid derivatives. In particular, we report exceptionally selective conditions for removing the C6 methyl protecting group by potassium hydroxide
Synthesis of oligosaccharides related to the HNK-1 antigen: I. Synthesis of selectively protected allyl 3-O-[methyl(β-D-glucopyranosyl)uronate]-β-D-galactopyranoside
Kornilov,Kononov,Zatonskii,Shashkov,Nifant'ev
, p. 597 - 607 (2007/10/03)
The glycosylation of several mono- and dihydroxyl glycosyl acceptors based on allyl β-D-galactopyranoside with completely acylated glucuronyl bromides under the Helferich reaction conditions was studied in order to develop a method for the preparative synthesis of selectively protected disaccharide β-D-GlcA-(1→3)-β-D-Gal in a form that can be used for further preparation of corresponding glycosyl donors and spacerated derivatives. We found that 1,2-orthoesters were the major primary products of the reaction, and their further conversion into isomeric glycosides depended on pH and can be regulated by the type of molecular sieves used. When Acid Washed Molecular Sieves AW 300 were used, glycosides were predominantly synthesized. No selective formation of the (1→3)-bound disaccharide was observed upon glycosylation of glycosyl acceptors with 2,3- and 3,4-diol groupings. This (1→3)-bound disaccharide was most efficiently synthesized by glycosylation of allyl 4,6-O-benzylidene-2-O-benzoyl-β-D-galactopyranoside with pivaloylated glucuronyl bromide. With acetylated or benzoylated glucuronyl bromides or with pivaloyl glucuronyl imidate, this galactoside can also be glycosylated but with a lower yield of the target (1→3)-bound disaccharide and lower glycosylation regioselectivity.
