104-29-0Relevant articles and documents
A New and Efficient Heterogeneous System for the Oxidative Cleavage of 1,2-Diols and the Oxidation of Hydroquinones
Daumas, M.,Vo-Quang, Y.,Vo-Quang, L.,Goffic, F. Le
, p. 64 - 65 (1989)
Sodium periodate/wet silica gel in the presence of dichloromethane is an efficient reagent for the oxidative cleavage of 1,2-diols and the oxidation of hydroquinones.This easily prepared reagent provides a good alternative of classical metaperiodate oxidation, especially for the preparation of aldehydes, which easily form hydrates.
Kinetics and mechanism of degradation of chlorphenesin carbamate in strongly acidic aqueous solutions
Hara,Hayashi,Yoshida
, p. 3481 - 3484 (1986)
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Exploration of the expeditious potential of Pseudomonas fluorescens lipase in the kinetic resolution of racemic intermediates and its validation through molecular docking
Soni, Surbhi,Dwivedee, Bharat P.,Sharma, Vishnu K.,Patel, Gopal,Banerjee, Uttam C.
, p. 85 - 94 (2017/12/26)
A profoundly time-efficient chemoenzymatic method for the synthesis of (S)-3-(4-chlorophenoxy)propan-1,2-diol and (S)-1-chloro-3-(2,5-dichlorophenoxy)propan-2-ol, two important pharmaceutical intermediates, was successfully developed using Pseudomonas fluorescens lipase (PFL). Kinetic resolution was successfully achieved using vinyl acetate as acylating agent, toluene/hexane as solvent, and reaction temperature of 30°C giving high enantioselectivity and conversion. Under optimized condition, PFL demonstrated 50.2% conversion, enantiomeric excess of 95.0%, enantioselectivity (E?=?153) in an optimum time of 1?hour and 50.3% conversion, enantiomeric excess of 95.2%, enantioselectivity (E?=?161) in an optimum time of 3?hours, for the two racemic alcohols, respectively. Docking of the R- and S-enantiomers of the intermediates demonstrated stronger H-bond interaction between the hydroxyl group of the R-enantiomer and the key binding residues of the catalytic site of the lipase, while the S-enantiomer demonstrated lesser interaction. Thus, docking study complemented the experimental outcome that PFL preferentially acylated the R form of the intermediates. The present study demonstrates a cost-effective and expeditious biocatalytic process that can be applied in the enantiopure synthesis of pharmaceutical intermediates and drugs.
A synthesis method of chlorphenesin
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Paragraph 0082; 0083, (2017/09/01)
The invention relates to a synthetic method of chlorobenzene glyceryl ether. 3-chloro-1,2-propanediol and parachlorophenol are directly used as raw materials, high-corrosion chemical solvents are not introduced, a reaction is simple, the yield is high, and the yield can reach 95 percent or more under the optimal reaction condition. By adding a few phase transfer catalysts, the reaction can be promoted to be conducted quickly and effectively, and the reaction time can be shortened by at least two hours.
