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104189-85-7

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104189-85-7 Usage

General Description

1H-Benzimidazole-1-acetic acid, 2,3-dihydro-2-oxo-(9CI) is a chemical compound with the molecular formula C10H9N3O3. It is a derivative of benzimidazole and contains both a carboxylic acid group and a ketone group. 1H-Benzimidazole-1-aceticacid,2,3-dihydro-2-oxo-(9CI) has potential pharmaceutical applications, particularly as an antihypertensive agent due to its ability to inhibit the angiotensin-converting enzyme (ACE). Additionally, it has been studied for its antimicrobial and antifungal properties, showing potential as a treatment for various infections. The precise mechanism of action and potential side effects of this compound are still under investigation, but its unique structure and properties make it an interesting candidate for further research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 104189-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,1,8 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 104189-85:
(8*1)+(7*0)+(6*4)+(5*1)+(4*8)+(3*9)+(2*8)+(1*5)=117
117 % 10 = 7
So 104189-85-7 is a valid CAS Registry Number.

104189-85-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-oxo-3H-benzimidazol-1-yl)acetic acid

1.2 Other means of identification

Product number -
Other names 1(3)-carboxymethylbenzimidazolin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104189-85-7 SDS

104189-85-7Downstream Products

104189-85-7Relevant articles and documents

Benzimidazoles as NMDA glycine-site antagonists: Study on the structural requirements in 2-position of the ligand

Dannhardt, Gerd,Kohl, Beate K.

, p. 123 - 129 (2000)

A series of different substituted benzimidazole derivatives has been synthesized and evaluated for the ability to displace [3H]MDL-105,519 to rat cortical membranes. Two benzimidazole-2-carboxylic acids 9 b and 9 c, in this substitution pattern not yet described as glycine antagonists, showed IC50 values of 0.89 μM (9 b) and 38.0 μM (9 c). Replacement of the carboxylate function in 2-position by a sulfonic acid moiety appreciably increased solubility, but decreased the affinity giving evidence for the strong need of the carboxylate group within the ligand. Further structure-activity studies using benzimidazol-2-one derivatives with an acetic acid moiety adjacent to a ring nitrogen revealed new insights into the importance of amide functionalities within the heterocycle for the affinity of antagonist glycine-site ligands.

SYNTHESIS OF N-CARBOXYALKYLBENZIMIDAZOLIN-2-ONES

Khalikov, S. S.,Kadyrov, Ch. Sh.,Ayupova, A. T.,Molchanov, L. V.

, p. 1251 - 1254 (1985)

The corresponding N-mono and N,N'-dicarboxyalkylbenzimidazolin-2-ones were prepared by the reaction of the sodium salts of benzimidazolin-2-one and its 1,5,6-substituted derivatives with chloroacetic acid, acrylonitrile. and γ-butyrolactone.

THIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS

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Page/Page column 116, (2008/06/13)

The invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, which are antagonist of the CXCR3 chemokine receptor useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.

Ramoplanin derivatives possessing antibacterial activity

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Page/Page column 67, (2010/11/23)

Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

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