104267-73-4

• 

• Basic information

  1. Product Name: 10-HYDROXY-9-NITROCAMPTOTHECIN
  2. Synonyms: 9-NITRO-10-HYDROXYCAMPTOTHECIN;10-HYDROXY-9-NITROCAMPTOTHECIN;(4S)-4-Ethyl-4,9-dihydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;9-Hydroxy-10-nitrocamptothecin
  3. CAS NO:104267-73-4
  4. Molecular Formula: C₂₀H₁₅N₃O₇
  5. Molecular Weight: 409.35
  6. EINECS: N/A
  7. Product Categories: Pharmaceutical Raw Materials
  8. Mol File: 104267-73-4.mol
  9. Article Data: 6

• Chemical Properties

  1. Melting Point: 205-208℃
  2. Boiling Point: 825.3°Cat760mmHg
  3. Flash Point: 452.9°C
  4. Appearance: /
  5. Density: 1.71
  6. Vapor Pressure: 7.58E-29mmHg at 25°C
  7. Refractive Index: 1.791
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 10-HYDROXY-9-NITROCAMPTOTHECIN(CAS DataBase Reference)
  11. NIST Chemistry Reference: 10-HYDROXY-9-NITROCAMPTOTHECIN(104267-73-4)
  12. EPA Substance Registry System: 10-HYDROXY-9-NITROCAMPTOTHECIN(104267-73-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 104267-73-4(Hazardous Substances Data)

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  Cas No: 104267-73-4

• USD $ 139.0-210.0 / Kilogram

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• 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,9-dihydroxy-10-nitro-, (4S)-

  Cas No: 104267-73-4

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• 10-HYDROXY-9-NITROCAMPTOTHECIN CAS NO.: 104267-73-4

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• 9-Nitrocamptothecin 104267-73-4

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• Hunan Russell Chemicals Technology Co.,Ltd
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• 9-nitro-10-hydroxycamptothecin

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• SAGECHEM LIMITED
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• 9-Hydroxy-10-nitrocamptothecin 104267-73-4

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104267-73-4 Usage

General Description

10-HYDROXY-9-NITROCAMPTOTHECIN is a chemical compound that belongs to the camptothecin family, which is known for its potent anti-cancer properties. It is a derivative of the natural compound camptothecin, and its structure includes a hydroxyl group and a nitro group. 10-HYDROXY-9-NITROCAMPTOTHECIN has been studied for its potential as a chemotherapeutic agent, particularly in the treatment of various types of cancer. It has shown promising results in inhibiting the growth of cancer cells by interfering with their DNA replication and causing cell death. Research is ongoing to explore its potential as a treatment for cancer and other conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 104267-73-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,2,6 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 104267-73:
(8*1)+(7*0)+(6*4)+(5*2)+(4*6)+(3*7)+(2*7)+(1*3)=104
104 % 10 = 4
So 104267-73-4 is a valid CAS Registry Number.

InChI:InChI=1/C20H15N3O7/c1-2-20(27)12-6-14-16-9(7-22(14)18(25)11(12)8-30-19(20)26)5-10-13(21-16)3-4-15(24)17(10)23(28)29/h3-6,24,27H,2,7-8H2,1H3/t20-/m0/s1

104267-73-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name	10-HYDROXY-9-NITROCAMPTOTHECIN

1.2 Other means of identification

Product number	-
Other names	9-Nitro-10-Hydroxy camptothecin

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104267-73-4 SDS

104267-73-4Upstream product

• 870527-52-9 1,2,6,7-tetrahydro-(20S)-camphthotecine 
• 7689-03-4 camptothecin 
• 19685-09-7 (S)-10-hydroxycamptothecin 

104267-73-4Downstream Products

• 172917-94-1 Benzenesulfonic acid (S)-4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 91421-43-1 9-amino-20(S)-camptothecin 
• 91421-42-0 rubitecan 
• 172917-96-3 4-nitro-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 909094-10-6 4-bromo-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 172917-97-4 4-methoxy-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 164159-91-5 4-fluoro-benzenesulfonic acid 4-ethyl-4-hydroxy-10-nitro-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 164159-99-3 9-nitro-10-(p-toluenesulfonyl)camptothecin 

104267-73-4Relevant articles and documents

A new high yield semisynthetic approach to (20S)-9-NH2-Camptothecin based on a sequence of palladium-catalysed reductions

Cabri, Walter,Candiani, Ilaria,Zarini, Franco,Penco, Sergio,Bedeschi, Angelo

, p. 9197 - 9200 (1995)

A new 5-step synthesis of 9-NH2-Camptothecin starting from natural Camptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.

Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Zheng, Qi-Huang

, p. 3865 - 3869 (2005)

Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy- 20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)- camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)- camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl] -10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.

Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives

Bedeschi, Angelo,Zarini, Franco,Cabri, Walter,Candiani, Ilaria,Penco, Sergio,Capolongo, Laura,Ciomei, Marina,Farao, Mariella,Grandi, Maria

, p. 671 - 674 (2007/10/03)

A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.

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