104849-39-0Relevant articles and documents
Open "D" ring hormone analogs
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, (2008/06/13)
Compounds of the formula: STR1 and the pharmaceutically acceptable esters thereof, wherein rings A and B are selected from the group consisting of STR2 wherein x represents an aromatic ring, or the presence or absence of 0, 1, or 2 conjugated or unconjugated ? bond(s), and wherein x represents the presence or absence of 0, 1, or 2 conjugated or unconjugated ? bond(s), and wherein a non-aromatic ? bond, if present, may optionally be converted to an epoxide; and wherein the dotted line represents the presence or absence of a ? bond, and wherein: R1 is H, acyl(1-6), or alkyl(1-6); R2 is H, alkyl(1～6), 2-propynyl, or allenyl; R3 and R4 is each independently H or OR5, wherein R5 is H, acyl(1-6), or alkyl(1-6); and wherein R1 and R2 is each independently H, alkyl(1-6) or is --C CR3, --CH=CHR3, or --CH=C=CHR3, wherein R3 is selected from the group consisting of H, halo, CF3, alkyl(1-6), acyloxy, carboxylate, carboalkoxylate, alkoxy, or alkylthio; and wherein when at least one of R1 and R2 is H, the compound of Formula 1 may also be in the oxidized oxo form and when both R1 and R2 are H, the compound of Formula 1 may also be in the oxidized carboxylic acid form or the alkyl(1-6) ester thereof are useful in regulating steroid metabolism.
