105350-26-3 Usage
Description
2-[[3-(2-QUINOLINYLMETHOXY)PHENYL]AMINO]BENZOIC ACID HYDROCHLORIDE, also known as SR 2640 Hydrochloride, is a chemical compound with a complex structure that features a quinolinium moiety attached to a benzoic acid backbone. It is a potent and selective antagonist of the leukotriene D4 (LTD4) and leukotriene E4 (LTE4) receptors.
Uses
Used in Pharmaceutical Industry:
2-[[3-(2-QUINOLINYLMETHOXY)PHENYL]AMINO]BENZOIC ACID HYDROCHLORIDE is used as an intermediate in the synthesis of drugs targeting inflammatory and allergic conditions. Its potent and selective antagonism of LTD4 and LTE4 receptors makes it a valuable compound for developing therapeutic agents that can modulate the immune response and alleviate symptoms associated with these conditions.
Used in Research Applications:
In addition to its pharmaceutical applications, 2-[[3-(2-QUINOLINYLMETHOXY)PHENYL]AMINO]BENZOIC ACID HYDROCHLORIDE is also used as a research tool to study the role of leukotrienes in various biological processes. By selectively blocking the action of LTD4 and LTE4, researchers can gain insights into the mechanisms underlying inflammation, allergy, and other related conditions, potentially leading to the discovery of new therapeutic targets and strategies.
Biological Activity
Potent and selective competitive leukotriene D 4 and E 4 receptor antagonist. Inhibits LTD 4 - but not histamine-induced guinea pig ileum and trachea contraction (pA 2 = 8.7). Also inhibits LTD 4 -attenuation of human PMN chemotaxis. Orally active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 105350-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,5 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 105350-26:
(8*1)+(7*0)+(6*5)+(5*3)+(4*5)+(3*0)+(2*2)+(1*6)=83
83 % 10 = 3
So 105350-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27)
105350-26-3Relevant articles and documents
Pyridyl and quinoline derivatives
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, (2008/06/13)
The present invention relates to compounds of formula I STR1 in which formula I X stands for O, S, STR2 R1 and R2 which can be the same or different stand for hydrogen, straight or branched, saturated or unsaturated, unsubstituted or