105538-07-6

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• Basic information

  1. Product Name: 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE
  2. Synonyms: 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE;3-Pyridazinamine, 6-(4-fluorophenyl)-;6-(4-Fluorophenyl)pyridazin-3-amine, 1-(6-Aminopyridazin-3-yl)-4-fluorobenzene;6-(4-fluorophenyl)pyridazin-3-aMine
  3. CAS NO:105538-07-6
  4. Molecular Formula: C₁₀H₈FN₃
  5. Molecular Weight: 189.19
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 105538-07-6.mol
  9. Article Data: 7

• Chemical Properties

  1. Melting Point: 165-168 °C
  2. Boiling Point: 398.024 °C at 760 mmHg
  3. Flash Point: 194.518 °C
  4. Appearance: /
  5. Density: 1.281 g/cm³
  6. Vapor Pressure: 0mmHg at 25°C
  7. Refractive Index: 1.611
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 4.67±0.10(Predicted)
  11. CAS DataBase Reference: 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE(CAS DataBase Reference)
  12. NIST Chemistry Reference: 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE(105538-07-6)
  13. EPA Substance Registry System: 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE(105538-07-6)

• Safety Data

  1. Hazard Codes: Xi
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 105538-07-6(Hazardous Substances Data)

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• CAS 105538-07-6 3-AMINO-6-(4-FLUOROPHENYL)PYRIDAZINE

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• 3-Pyridazinamine,6-(4-fluorophenyl)-

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• 3-Pyridazinamine,6-(4-fluorophenyl)-

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• 6-(4-fluorophenyl)pyridazin-3-amine

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105538-07-6 Usage

General Description

3-Amino-6-(4-fluorophenyl)pyridazine is a chemical compound with the molecular formula C10H8FN3. It belongs to the pyridazines class of organic compounds, which are heterocyclic compounds containing a pyridazine ring system, a six-membered heterocycle with two nitrogen atoms at positions 1 and 2. This chemical is characterized by the presence of an amino group at position 3 and a 4-fluorophenyl group at position 6 of the pyridazine ring. It is commonly used in the synthesis of pharmaceutical compounds and agrochemicals due to its versatile chemical reactivity and potential biological activity. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery due to its unique molecular structure and potential interactions with biological targets.

Check Digit Verification of cas no

The CAS Registry Mumber 105538-07-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,5,3 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 105538-07:
(8*1)+(7*0)+(6*5)+(5*5)+(4*3)+(3*8)+(2*0)+(1*7)=106
106 % 10 = 6
So 105538-07-6 is a valid CAS Registry Number.

InChI:InChI=1/C10H8FN3/c11-8-3-1-7(2-4-8)9-5-6-10(12)14-13-9/h1-6H,(H2,12,14)

105538-07-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	6-(4-fluorophenyl)pyridazin-3-amine

1.2 Other means of identification

Product number	-
Other names	PC3314

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105538-07-6 SDS

105538-07-6Upstream product

• 88490-21-5 [6-(4-Fluoro-phenyl)-pyridazin-3-yl]-hydrazine 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 1765-93-1 4-fluoroboronic acid 
• 187973-60-0 6-iodopyridazine-3-amine 
• 58897-67-9 6-(p-fluorophenyl)-3(2H)-pyridazinone 
• 66548-52-5 3-chloro-6-(4-fluorophenyl)pyridazine 

105538-07-6Downstream Products

• 1421637-33-3 N-butyl-3-(4-fluorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-34-4 N-cyclohexyl-3-(4-fluorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-35-5 N-propyl-3-(4-fluorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-36-6 N-allyl-3-(4-fluorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-47-9 3-(4-fluorophenyl)-[1,3]thiazolo[4,5-c]pyridazin-6-amine 
• 1421637-26-4 3-amino-4-bromo-6-(4-fluorophenyl)pyridazine 

105538-07-6Relevant articles and documents

Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization

Majewski, Mark W.,Gandhi, Disha M.,Rosas, Ricardo,Kodali, Revathi,Arnold, Leggy A.,Dockendorff, Chris

, p. 121 - 126 (2019)

A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2. Modified versions of the PAR1 antagonist RWJ-58259 containing alkyne adapters were connected via cycloaddition reactions to azide-capped polyethylene glycol (PEG) spacers attached to imidazopyridazine-based PAR2 antagonists. Initial studies of the PAR1-PAR2 antagonists indicated that they inhibited G alpha q-mediated calcium mobilization in endothelial and cancer cells driven by both PAR1 and PAR2 agonists. Compounds of this novel class hold promise for the prevention of restenosis, cancer cell metastasis, and other proliferative disorders.

Mild and direct access to 7-substituted-4-trifluoromethylpyrimido[1,2- b ]pyridazin-2-one systems

Petrignet, Julien,Thiery, Emilie,Silpa, Laurence,Abarbri, Mohamed

, p. 947 - 954 (2014/04/03)

New and efficient methods for the synthesis of 7-substituted-4- trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtained in good to excellent yields from 3-amino-6-chloropyridazine and ethyl 4,4,4-trifluorobut-2- ynoate. Georg Thieme Verlag Stuttgart · New York.

Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531)

Gavande, Navnath,Johnston, Graham A. R.,Hanrahan, Jane R.,Chebib, Mary

supporting information; experimental part, p. 4131 - 4136 (2010/10/18)

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2,3,6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-95531) has been achieved using a versatile strategy in four steps and 73% overall yield.

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