105757-72-0Relevant articles and documents
Synthesis and biological evaluation of a new series of N-ylides as protein farnesyltransferase inhibitors
Abuhaie, Cristina-Maria,Ghinet, Alina,Farce, Amaury,Dubois, Jo?lle,Rigo, Beno?t,B?cu, Elena
, p. 5887 - 5892 (2013)
A new family of 30 benzoylated N-ylides 4 and 5 was synthesized and evaluated for the inhibitory activity on human protein farnesyltransferase. Most of these novel compounds possessed in vitro inhibition potencies in the micromolar range. The nature of th
Oral Hypoglycemic Agents. Discovery and Structure-Activity Relationships of Phenacylimidazolium Halides
Dominianni, Samuel J.,Yen, Terence T.
, p. 2301 - 2306 (2007/10/02)
Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides.Compounds 2 and 3 produced reductions of ca. 40percent 2 h after doses of 100 mg/kg po.Since these mice do not respond to sulfonylureas, the glucose-lowering activity of phenacylimidazolium salts in this model suggests a mechanism other than that of stimulating insulin secretion.Only phenacylimidazolium halides with electron-donating groups were active; other azolium salts or variations in the phenacyl portion (alterations in the keto function; chain lengthening or extensive branching) produced inactive compounds.