105812-81-5Relevant articles and documents
An efficient and stereoselective synthesis of (3S,4R)-(-)-trans-4- (4′-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine
Somaiah, Sripathi,Sashikanth, Suthrapu,Raju, Veeramalla,Reddy, Karnati Venugopal
, p. 1 - 3 (2011)
An asymmetric conjugate addition reaction between a chiral α,β-unsaturated amido ester and ethyl-N-methylmalonamide has been used as a key step in the synthesis of (3S,4R)-(-)-trans-4-(4′- fluorophenyl)-3-hydroxymethyl-N-methylpiperidine, a key intermediate for (-)-paroxetine.
Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
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Page/Page column 35, (2010/11/27)
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. [image]
PROCESS FOR PRODUCING PIPERIDINE COMPOUND
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Page 9, (2008/06/13)
The present invention.relates to a new process for preparing a pharmaceutical intermediate compound of formula (I). In the formula, Rl represents hydrogen, straight or branched C1-10 alkyl with or without substituent(s), straight or branched C1-10 alkoxy with or without substituent(s), aryl with or without substituent(s), formyl or alkylcarbonyl. Using the process according to the present invention, the intermediate compound for the preparation of aroxetine can be simply prepared with a high product yield and a high purity of 99% or more, without carrying out any dangerous processes.