1061-93-4Relevant articles and documents
Isolation, chemical analysis, and study of the hypolipidemic activity of the total flavonoid extract from thermopsis altherniaflora
Khushbaktova,Faizieva,Syrov,Yuldashev,Batirov,Mamatkhanov
, p. 155 - 158 (2001)
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Flavonoids from the aerial part of Vicia subvillosa
Yuldashev
, p. 99 - 100 (2005)
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Flavonoids and coumarins from Allium rotundum
Maisashvili,Gvazava,Kuchukhidze
, p. 87 - 88 (2009)
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Extraction, Isolation and Characterization of Valuable Worked on Acacia Tortilis
Muhaisen, Hasan M. H.
, p. 6731 - 6747 (2021/11/01)
Acacia tortilis is one of the important species of genus Acacia belonging to family Leguminaceae. Though there is no more study performed on this plant but it plays important role in the countries where it found. These countries include North Africa, Arabian Peninsula and Asian countries. The various part of Acacia tortilis plant say leaves, pods, gum exudates and bark were used as antidiabetic, antidiarrhoeal, antiasthmatic and also had several other medicinal benefits. The present discussion deals with the isolation and characterization of the following compounds from the leaves of Acacia tortilis. Lupan-3-ol, 12,20-diene, Lupan-12, 20-dien 3-one, Friedelin, ?-amyrin, ?- sitosterol, Apigenin, Luteolin, Quercetin, 5,7-dihydroxy-4-p-methyl benzylisoflavone, Vitexin, 2',6'-dihydroxy chalcone-4'-O-glucoside.
Synthesis, characterization, anti-inflammatory and anti-proliferative activity against MCF-7 cells of O-alkyl and O-acyl flavonoid derivatives
Hoang, T. Kim-Dung,Huynh, T. Kim-Chi,Nguyen, Thanh-Danh
, p. 45 - 52 (2015/10/12)
A series of O-alkyl and O-acyl flavonoid derivatives was synthesized in high efficiency. Alkylation and acylation of 5-hydroxyflavonoids showed that the low reactivity hydroxyl group, 5-OH, well reacted with strong reagents whereas with weaker reagents, the different products were obtained dependently on structural characteristic of ring C of respective flavonoid. In order to evaluate anti-inflammatory activity, all compounds were tested for in vitro inhibition of bovine serum albumin denaturation and in vivo inhibition of carrageenan-induced mouse paw edema. Among them, the compounds 3, 3b, 4b and 4c demonstrated more effective anti-inflammatory activity than standard drugs (diclofenac sodium and ketoprofen) in both tests. Meanwhile, the flavonoids 2, 2c, 3a and 4b displayed anti-proliferative activity against MCF-7 cell lines. Triacetyl derivative of hesperetin 4b inducing degradation of DNA in MCF-7 cells was observed.
