107507-53-9

• 

• Basic information

  1. Product Name: 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine
  2. Synonyms: 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine
  3. CAS NO:107507-53-9
  4. Molecular Formula: C₈H₁₀F₃N₃S
  5. Molecular Weight: 237.25
  6. EINECS: N/A
  7. Product Categories: pharmacetical
  8. Mol File: 107507-53-9.mol
  9. Article Data: 5

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 300.3°Cat760mmHg
  3. Flash Point: 135.4°C
  4. Appearance: /
  5. Density: 1.363g/cm³
  6. Vapor Pressure: 0.00113mmHg at 25°C
  7. Refractive Index: 1.501
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine(CAS DataBase Reference)
  11. NIST Chemistry Reference: 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine(107507-53-9)
  12. EPA Substance Registry System: 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine(107507-53-9)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 107507-53-9(Hazardous Substances Data)

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• Piperazine,1-[4-(trifluoromethyl)-2-thiazolyl]-

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107507-53-9 Usage

General Description

1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine is a chemical compound that contains a piperazine ring and a trifluoromethyl-thiazol group. It is commonly used in medicinal chemistry and drug development as a building block for various compounds targeting central nervous system disorders, such as schizophrenia and depression. 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine has shown potential in modulating different neurotransmitter systems, including serotonin and dopamine, which are important for the regulation of mood and behavior. Additionally, its trifluoromethyl group enhances its pharmacokinetic properties, making it more potent and stable in the body. Its unique structure and properties make it a valuable tool for the development of new pharmaceuticals targeting neurological and psychiatric disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 107507-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,5,0 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 107507-53:
(8*1)+(7*0)+(6*7)+(5*5)+(4*0)+(3*7)+(2*5)+(1*3)=109
109 % 10 = 9
So 107507-53-9 is a valid CAS Registry Number.

InChI:InChI=1/C8H10F3N3S/c9-8(10,11)6-5-15-7(13-6)14-3-1-12-2-4-14/h5,12H,1-4H2

107507-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	2-piperazin-1-yl-4-(trifluoromethyl)-1,3-thiazole

1.2 Other means of identification

Product number	-
Other names	QC-6199

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107507-53-9 SDS

107507-53-9Upstream product

• 431-35-6 3-bromo-1,1,1-trifluoroacetone 
• 54147-47-6 1-piperazine carbothioamide 
• 110-85-0 piperazine 
• 228119-52-6 2-Chloro-4-(trifluoromethyl) thiazole 
• 668484-48-8 tert-butyl 4-(4-(trifluoromethyl)thiazol-2-yl)piperazine-1-carboxylate 

107507-53-9Downstream Products

• 1095535-04-8 (1R,2R)-N-(1-cyanocyclopropyl)-2-({4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazin-1-yl}carbonyl)cyclohexanecarboxamide 

107507-53-9Relevant articles and documents

Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition

Dossetter, Alexander G.,Bowyer, Jonathan,Cook, Calum R.,Crawford, James J.,Finlayson, Jonathan E.,Heron, Nicola M.,Heyes, Christine,Highton, Adrian J.,Hudson, Julian A.,Jestel, Anja,Krapp, Stephan,MacFaul, Philip A.,McGuire, Thomas M.,Morley, Andrew D.,Morris, Jeffrey J.,Page, Ken M.,Ribeiro, Lyn Rosenbrier,Sawney, Helen,Steinbacher, Stefan,Smith, Caroline

scheme or table, p. 5563 - 5568 (2012/09/22)

The discovery of nitrile compound 4, a potent inhibitor of Cathepsin K (Cat K) with good bioavailability in dog is described. The compound was used to demonstrate target engagement and inhibition of Cat K in an in vivo dog PD model. The margin to hERG ion channel inhibition was deemed too low for a clinical candidate and an optimisation program to find isosteres or substitutions on benzothiazole group led to the discovery of 20, 24 and 27; all three free from hERG inhibition.

[4-(HETEROARYL) PIPERAZIN-1-YL]-(2,5-SUBSTITUTED -PHENYL)METHANONE DERIVATIVES AS GLYCINE TRANSPORTER 1 (GLYT-1) INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS

-

Page/Page column 59-60, (2008/06/13)

The present invention relates to compounds of the general formula (I) wherein R1 is-OR1’,-SR1’ or is a heterocycloalkyl group; R1’ is lower alkyl, lower alkyl substituted by halogen or is -(CH2)n

1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents

-

, (2008/06/13)

Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.

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