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107555-38-4

107555-38-4

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107555-38-4 Usage

General Description

Ethyl 6,8-difluoro-4-hydroxyquinoline-3-carboxylate is a synthetic chemical compound with the molecular formula C14H10F2NO4. It belongs to the family of quinoline derivatives and is commonly used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical products. The compound is known for its anti-bacterial, anti-inflammatory, and anti-cancer properties, making it a valuable ingredient in the development of new medications. Ethyl 6,8-difluoro-4-hydroxyquinoline-3-carboxylate is synthesized through chemical reactions involving ethyl esters and quinoline-3-carboxylic acid, and its structure and properties are studied for potential applications in medicine and pharmacology.

Check Digit Verification of cas no

The CAS Registry Mumber 107555-38-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,5,5 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 107555-38:
(8*1)+(7*0)+(6*7)+(5*5)+(4*5)+(3*5)+(2*3)+(1*8)=124
124 % 10 = 4
So 107555-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H9F2NO3/c1-2-18-12(17)8-5-15-10-7(11(8)16)3-6(13)4-9(10)14/h3-5H,2H2,1H3,(H,15,16)

107555-38-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 6,8-difluoro-4-hydroxyquinoline-3-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 6,8-difluoro-4-oxo-1H-quinoline-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107555-38-4 SDS

107555-38-4Relevant articles and documents

Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

Carta, Davide,Brun, Paola,Dal Pra, Matteo,Bernabè, Giulia,Castagliuolo, Ignazio,Ferlin, Maria Grazia

, p. 1017 - 1032 (2018/06/27)

Our aim was to identify new multi-target compounds endowed with both anti-inflammatory and anti-bacterial activities for treatment of human infections. Diflunisal, a nonsteroidal anti-inflammatory agent, has recently been repurposed for its anti-virulence properties against methicillin-resistant Staphylococcus aureus. Effective synthesis of some aza-analogs of the anti-inflammatory drug diflunisal was carried out following the route involving key oxazole intermediates to obtain o- and m-hydroxypyridinecarboxylic acid derivatives. The newly synthesized diflunisal aza-analogs did not exhibit cytotoxic activity up to 80 μM and some of them exhibited anti-inflammatory activities, decreasing the levels of pro-inflammatory cytokines and prostaglandins induced by bacterial lipopolysaccharide in human primary macrophages. Ten of the diflunisal aza-analogs were found to have interesting antibacterial activity, sensitizing S. aureus, Streptococcus pyogenes, Enterococcus faecium, and Pseudomonas aeruginosa to the antibacterial effects of beta-lactam antibiotics and protein synthesis inhibitors.

Antibacterial activity of 6,8-disubstituted-quinolone-3-carboxylic acids

Krishnan,Lang Jr.

, p. 1185 - 1187 (2007/10/02)

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