108097-77-4Relevant articles and documents
Synthesis and pharmacologic evaluation of some dihydropyran carboxylic acids
Coudert,Couquelet,Fialip,Sannajust,Bastide,Eschalier
, p. 145 - 158 (2007/10/02)
The synthesis of three new dihydropyran carboxylic acids has been performed by uncommon procedures: cyanosilylation, cyclisation of oxime. Their chemical structure was confirmed by I.R. and N.M.R. data. In a pharmacological evaluation they were found to possess significant effects on the passive cutaneous anaphylaxis test and on the central nervous system; one of them showed an interesting antiallergic effect whilst another showed an interesting sedative effect.