108180-63-8Relevant articles and documents
Competitive ortho metalation effects: The kinetic and thermodynamic lithiation of 3-(tert-butoxycarbonyl)amino-4-carbomethoxythiophene
Carroll, William A.,Zhang, Xiaolin
, p. 2637 - 2640 (1997)
Deprotanation of the thiophene 1 under kinetically controlled conditions with LDA takes place next to the NHBoc group and under thermodynamic conditions next to the methyl eater. N-Methylation leads to exclusive lithiation next to the ester. The methylester was found to be superior to the diethylamide in facilitating lithiation.
SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
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, (2008/06/13)
The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
Synthesis of Thiophenedicarbonyldiazides and Di-t-butyl Thiophendicarbamates
Galvez, Carmen,Garcia, Francisco,Garcia, Juan,Soldevila, Joan
, p. 1103 - 1108 (2007/10/02)
Dicarbamates 1b and 1c, and dicarbonyldiazides 2b and 2c are obtained in good yields starting from thiophenedicarboxylic acids 3b and 3c, but the vicinal diacids 3a and 3d are not suitable for the synthesis of dicarbamates 1a and 1d and dicarbonyldiazides 2a and 2d; 1a is prepared by a stepway procedure previously described, and 1d by t-butoxycarbonylation of the recently known 3,4-thiophenediamine.
