1096-48-6Relevant articles and documents
Sensitive fluorescent vesicles based on the supramolecular inclusion of β-cyclodextrins with N-alkylamino-L-anthraquinone
Sun, Tao,Zhang, Huacheng,Yan, Hui,Li, Jianye,Cheng, Guanghui,Hao, Aiyou,Qiao, Hongwei,Xin, Feifei
, p. 351 - 364 (2011)
Self-assembly fluorescent vesicles were designed and prepared based on the supramolecular interaction of cyclodextrins and N-alkylamino-L-anthraquinone (n-AQ). As the guest molecules, n-AQs with alkyl lengths ranging from C 0 to C18 were synthesised by the direct reaction of alkylamine with L-nitroanthraquinone in N,N-dimethylformamide. Transmission electron microscopy (TEM), scanning electron microscopy, dynamic light scattering and epi fluorescence microscopy were employed to study the vesicle system in detail. The formation mechanism of the vesicles was suggested based on the results of TEM observation, UV spectrum, fluorescence spectrum, 1H NMR and simulation in the software Materials 4.3. The fluorescent vesicles show sensitive and multi-responsive properties to external stimuli. Based on these properties, we tried to use the vesicle as a new kind of fluorescence staining material for living cells. The vesicles can effectively stain the human breast cancer cells (MCF-7) and mice mononuclear macrophages (REW-264.7). This paper provides a better understanding in the design and preparation of drug delivery, biomaterials and intelligent materials.
Synthesis of 9-chloro-1,10-anthraquinone and its reactions with amines
Gorelik,Titova,Gladysheva
, p. 1141 - 1146 (2007/10/03)
1-Dichlorophosphoryloxy-9,9-dichloroanthrone, a product of the reaction between 1-hydroxyanthraquinone and PCl5, reacts with primary amines in benzene to give first 1-(diaminophosphoryloxy)-9,9-dichloroanthrones and then the corresponding 9-imines. The reaction in DMF occurs with elimination of the phosphoryloxy group and generation of 9-chloro-1,10-anthraquinone that undergoes amination followed by substitution of the hydrogen atom in position 4 rather than a chlorine atom in position 9, which is the most active position in 2,4,9-trichloro-1,10-anthraquinone. The second step of amination results in 4,9-di(alkylamino)-1,10-anthraquinone. The literature data on obtaining individual 9-chloro-1,10-anthraquinone under the action of bases on 1-dichorophosphoryloxy-9,9-dichloroanthrone were not experimentally supported.
Process for the preparation of 1-alkylamino-anthraquinones
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, (2008/06/13)
Process for the preparation of 1-alkylamino-anthraquinones which comprises reacting 1-nitroanthraquinone with a monoalkylamine in the presence of an ether, a hydrocarbon or a mixture of an ether and a hydrocarbon. The 1-alkylamino-anthraquinones which are obtained can be employed directly as dyestuffs or used, without further purification, for the production of dyestuffs. Process of the invention results in the procurement of 1-alkylamine-anthraquinones of high purity and in high yield and avoids the formation of undesired by-products.
