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110-85-0 Usage

General Description

1,4-Diazacyclohexane, also known as piperazine, is a chemical compound with the molecular formula C4H10N2. It is a heterocyclic organic compound containing two nitrogen atoms in a six-membered ring. Piperazine is commonly used as a pharmaceutical intermediate in the production of various medications, including antihistamines, anthelmintics, and antipsychotics. It is also utilized as a corrosion inhibitor, a precursor for rubber additives, and a component in some specialty solvents. Piperazine has also been studied for its potential use as a carbon dioxide absorbent in gas separation processes. Overall, 1,4-Diazacyclohexane has a wide range of industrial and pharmaceutical applications due to its versatile chemical properties.

Check Digit Verification of cas no

The CAS Registry Mumber 110-85-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 110-85:
(5*1)+(4*1)+(3*0)+(2*8)+(1*5)=30
30 % 10 = 0
So 110-85-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

110-85-0 Well-known Company Product Price

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  • Alfa Aesar

  • (A15049)  Piperazine, anhydrous, 99%   

  • 110-85-0

  • 100g

  • 190.0CNY

  • Detail
  • Alfa Aesar

  • (A15049)  Piperazine, anhydrous, 99%   

  • 110-85-0

  • 500g

  • 374.0CNY

  • Detail
  • Alfa Aesar

  • (A15049)  Piperazine, anhydrous, 99%   

  • 110-85-0

  • 1kg

  • 582.0CNY

  • Detail
  • Alfa Aesar

  • (A15049)  Piperazine, anhydrous, 99%   

  • 110-85-0

  • 2500g

  • 1078.0CNY

  • Detail
  • Alfa Aesar

  • (A15049)  Piperazine, anhydrous, 99%   

  • 110-85-0

  • *5x500g

  • 1236.0CNY

  • Detail
  • Sigma-Aldrich

  • (94209)  Piperazine  analytical standard

  • 110-85-0

  • 94209-100MG

  • 595.53CNY

  • Detail
  • USP

  • (1541601)  Piperazine  United States Pharmacopeia (USP) Reference Standard

  • 110-85-0

  • 1541601-200MG

  • 4,662.45CNY

  • Detail

110-85-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name piperazine

1.2 Other means of identification

Product number -
Other names PIPERAZINE CHIPS

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110-85-0 SDS

110-85-0Synthetic route

2-(2-Aminoethylamino)ethanol
111-41-1

2-(2-Aminoethylamino)ethanol

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With hydrogen; sodium sulfate In 1,4-dioxane at 180℃; under 66756.7 Torr; for 6h; Reagent/catalyst; Autoclave;80.7%
With aluminum oxide; nitrogen at 400 - 450℃;
With 1,4-dioxane; nickel at 200℃;
iminodiacetonitrile
628-87-5

iminodiacetonitrile

A

piperazine
110-85-0

piperazine

B

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

Conditions
ConditionsYield
With ammonia; hydrogen; potassium hydroxide In ethanol at 80℃; under 90009 Torr; Pressure; Reagent/catalyst; Solvent; Temperature; Time;A 1.03%
B 97.53%
ethylene glycol
107-21-1

ethylene glycol

A

piperazine
110-85-0

piperazine

B

ethanolamine
141-43-5

ethanolamine

Conditions
ConditionsYield
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 155℃; under 42754.3 Torr; for 12h; Autoclave;
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 180℃; under 27002.7 Torr; for 12h; Autoclave;
With (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 155℃; for 12h; Temperature; Inert atmosphere; Autoclave;
ethylenediamine
107-15-3

ethylenediamine

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

A

piperazine
110-85-0

piperazine

B

1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

Conditions
ConditionsYield
With ZSM-5 type zeolite In water at 370℃; pH=10; Temperature; pH-value;A 63%
B 17%
With ZSM-5 type zeolite In water at 330℃; pH=10; Temperature; pH-value;A 44%
B 56%
With ZSM-5 type zeolite with Na exchange rate of 62percent In water at 290℃; Reagent/catalyst; Temperature;
With Na-ion exchanged ZSM-5 type zeolite In water at 290 - 600℃; Gas phase;
With β-type iron silicate at 320℃; Reagent/catalyst;
ethylene glycol
107-21-1

ethylene glycol

ethylenediamine
107-15-3

ethylenediamine

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With hydrogen; sodium sulfate at 210℃; under 88508.9 Torr; for 6h; Reagent/catalyst; Autoclave;70%
With 1,4-dioxane; hydrogen; nickel at 200℃; under 28 Torr;
With palladium on magnesium oxide In acetonitrile at 160℃; for 6.5h; Autoclave; Inert atmosphere;80 %Chromat.
aminoethylpiperazine
140-31-8

aminoethylpiperazine

A

piperazine
110-85-0

piperazine

B

1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

Conditions
ConditionsYield
With ZSM-5 type zeolite In water at 350℃;A 26%
B 53%
With water; Na-type ZSM-5(2) at 350 - 370℃;A 20.2%
B 47.7%
Na-type ZSM-5(6) at 355 - 380℃;A 18.9%
B 39.9%
2-[(3-aminopropyl)amino]ethanol
4461-39-6

2-[(3-aminopropyl)amino]ethanol

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With phosphorus pentachloride In tetrachloromethane at 30 - 60℃; for 20h; Inert atmosphere;90%
ethylenediamine
107-15-3

ethylenediamine

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With tetralin; nickel at 150℃;
With tetralin; hydrogen; nickel at 170℃;
With monoaluminum phosphate at 400 - 430℃;
Glycine anhydride
106-57-0

Glycine anhydride

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 180℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;84%
With i-Amyl alcohol; sodium
With sulfuric acid
With hydrogenchloride at 20℃;
ethylene glycol
107-21-1

ethylene glycol

A

piperazine
110-85-0

piperazine

B

ethanolamine
141-43-5

ethanolamine

C

ethylenediamine
107-15-3

ethylenediamine

Conditions
ConditionsYield
With ammonia; C28H44BNOP2Ru In toluene at 180℃; under 21002.1 Torr; for 24h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; hydrogen; chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II) In toluene at 180℃; under 49580 Torr; for 12h; Product distribution / selectivity; Autoclave; Inert atmosphere;
With ammonia; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 155℃; under 31503.2 Torr; for 12h; Autoclave;
1-(2,3-dihydroxy propyl)piperazine
7483-59-2

1-(2,3-dihydroxy propyl)piperazine

A

piperazine
110-85-0

piperazine

B

2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane
76950-43-1

2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane

Conditions
ConditionsYield
With solid catalyst from aluminum phosphate and cesium nitrate In water at 360℃; for 4h; Inert atmosphere; Large scale;A 22%
B 44%
With cesium phosphate and batium hydroxyapatite on Al2O3 In water at 390℃; for 24h; Reagent/catalyst; Temperature; Overall yield = 95 %;
oxirane
75-21-8

oxirane

A

piperazine
110-85-0

piperazine

B

triethanolamine
102-71-6

triethanolamine

C

ethanolamine
141-43-5

ethanolamine

D

ethylenediamine
107-15-3

ethylenediamine

E

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

F

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

Conditions
ConditionsYield
With ammonia; hydrogen; Ni-Re-B catalyst In water at 165℃; under 156079 Torr;
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

ethylenediamine
107-15-3

ethylenediamine

C

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

Conditions
ConditionsYield
With ammonia; hydrogen; Nickel/Rhenium/Boron (8.0:2.0: 1.7 wt. percent) catalyst on an alumina/silica (80:20) at 165℃; under 155909 Torr;
With ammonia; hydrogen at 170℃; under 60006 Torr; for 12h; Flow reactor;
1,4-bis(2-hydroxyethyl)piperazine
122-96-3

1,4-bis(2-hydroxyethyl)piperazine

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With hydrogen In water at 180℃; under 15001.5 Torr;
2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

A

piperazine
110-85-0

piperazine

B

aminoethylpiperazine
140-31-8

aminoethylpiperazine

Conditions
ConditionsYield
With ammonia; hydrogen In water at 190℃; under 150015 Torr; Temperature;A 42.5 %Chromat.
B 6.3 %Chromat.
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

ethylenediamine
107-15-3

ethylenediamine

Conditions
ConditionsYield
With ammonia; hydrogen In water at 159℃; under 4431.9 Torr; Reagent/catalyst;
ethylene glycol
107-21-1

ethylene glycol

A

piperazine
110-85-0

piperazine

B

ethylenediamine
107-15-3

ethylenediamine

Conditions
ConditionsYield
With chlorocarbonylhydrido[4,5-bis(dicyclohexylphosphinomethyl)acridine]ruthenium(II); potassium tert-butylate; ammonia In toluene at 180℃; under 35553.6 Torr; for 12h; Autoclave; Inert atmosphere;
ethanolamine
141-43-5

ethanolamine

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With hydrogen In 1,4-dioxane at 200℃; under 30003 Torr; Solvent;
With hydrogen In ethanol at 200℃; under 15001.5 Torr; Solvent; Temperature; Pressure;
aminoethylpiperazine
140-31-8

aminoethylpiperazine

ethylenediamine
107-15-3

ethylenediamine

A

piperazine
110-85-0

piperazine

B

1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

Conditions
ConditionsYield
With ZSM-5 type zeolite In water at 320℃; pH=9; Temperature; pH-value;A 54%
B 46%
1,4-pyrazine
290-37-9

1,4-pyrazine

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With potassium carbonate; [Ir(cod)(1-neopentyl-4-n-butyl-triazole-5-ylidene)PPh3]BF4 In isopropyl alcohol at 82℃; for 24h;100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In 1,4-dioxane at 75℃; under 37503.8 Torr; for 40h;87%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;31%

A

piperazine
110-85-0

piperazine

B

ethanolamine
141-43-5

ethanolamine

C

ethylenediamine
107-15-3

ethylenediamine

Conditions
ConditionsYield
With ammonia; hydrogen In tetrahydrofuran at 100℃; under 75007.5 Torr; for 8h; Autoclave;
2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

A

piperazine
110-85-0

piperazine

B

aminoethylpiperazine
140-31-8

aminoethylpiperazine

C

ethylenediamine
107-15-3

ethylenediamine

Conditions
ConditionsYield
With ammonia; hydrogen In water at 196℃; under 150015 Torr; Temperature;A 36.7 %Chromat.
B 6.7 %Chromat.
C 5.1 %Chromat.
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

2-(2-Aminoethylamino)ethanol
111-41-1

2-(2-Aminoethylamino)ethanol

C

ethylenediamine
107-15-3

ethylenediamine

D

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

Conditions
ConditionsYield
With ammonia; hydrogen
With ammonia; hydrogen
With ammonia; hydrogen at 170℃; under 60006 Torr; for 12h; Reagent/catalyst; Flow reactor;
With ammonia at 170℃; under 60006 Torr;
piperazine-1-carboxylic acid
10430-90-7

piperazine-1-carboxylic acid

methyloxirane
75-56-9, 16033-71-9

methyloxirane

A

piperazine
110-85-0

piperazine

B

1,2-propylene cyclic carbonate
108-32-7

1,2-propylene cyclic carbonate

Conditions
ConditionsYield
With potassium iodide at 160℃; for 10h; Reagent/catalyst;A 97.6%
B 95.3%
oxirane
75-21-8

oxirane

piperazine-1-carboxylic acid
10430-90-7

piperazine-1-carboxylic acid

A

piperazine
110-85-0

piperazine

B

[1,3]-dioxolan-2-one
96-49-1

[1,3]-dioxolan-2-one

Conditions
ConditionsYield
With zinc dibromide at 160℃; for 8.5h;A 97.7%
B 94.9%
1,4-bis-(toluene-4-sulfonyl)-piperazine
17046-84-3

1,4-bis-(toluene-4-sulfonyl)-piperazine

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
Stage #1: 1,4-bis-(toluene-4-sulfonyl)-piperazine With Na/K absorbed into silica gel In 1,2-dimethoxyethane at 60℃; Inert atmosphere;
Stage #2: With water In 1,2-dimethoxyethane
76%
With sulfuric acid at 170℃;
1,2-dichloro-ethane
107-06-2

1,2-dichloro-ethane

A

piperazine
110-85-0

piperazine

B

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine
112-57-2

N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

D

triethylentetramine
112-24-3

triethylentetramine

Conditions
ConditionsYield
With ammonium hydroxide; ethylenediamine In water at 100℃; under 18751.9 Torr;
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

aminoethylpiperazine
140-31-8

aminoethylpiperazine

C

ethylenediamine
107-15-3

ethylenediamine

D

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

Conditions
ConditionsYield
With ammonia; hydrogen In water at 80℃; under 26463 Torr; Temperature; Pressure;
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C

ethylenediamine
107-15-3

ethylenediamine

D

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

Conditions
ConditionsYield
With ammonia; hydrogen In water at 103℃; under 26463 Torr; Temperature;
2,5-dibromothiophen
3141-27-3

2,5-dibromothiophen

C10H9BrN2S

C10H9BrN2S

piperazine
110-85-0

piperazine

Conditions
ConditionsYield
With 1-(1-methylethyl)piperazine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,2-dimethoxyethane Inert atmosphere;74%
piperazine
110-85-0

piperazine

2-Chloroquinoline
612-62-4

2-Chloroquinoline

2-(piperazin-1-yl)quinoline
4774-24-7

2-(piperazin-1-yl)quinoline

Conditions
ConditionsYield
In ethylene glycol at 140℃; for 2h; Product distribution / selectivity;100%
In ethylene glycol at 140℃; for 2h;100%
With potassium hydroxide In toluene for 4h; Heating;83%
piperazine
110-85-0

piperazine

N,N'-dinitrosopiperazine
140-79-4

N,N'-dinitrosopiperazine

Conditions
ConditionsYield
With toluene-4-sulfonic acid; sodium nitrite In dichloromethane at 20℃; chemoselective reaction;100%
With sulfuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.166667h;99%
With cross-linked polyvinylpyrrolidone*N2O4; dinitrogen tetraoxide In dichloromethane at 20℃; for 0.333333h;98%
piperazine
110-85-0

piperazine

1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin
72553-83-4

1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin

1-Piperazino-4-phenyl-pyridazino<4,5-d>pyridazin
83490-52-2

1-Piperazino-4-phenyl-pyridazino<4,5-d>pyridazin

Conditions
ConditionsYield
In ethanol for 3h; Heating;100%
piperazine
110-85-0

piperazine

6-Methyluracil
626-48-2

6-Methyluracil

formaldehyd
50-00-0

formaldehyd

C-5,N-3-Dipiperazinomethylene-6-methyluracil
75682-13-2

C-5,N-3-Dipiperazinomethylene-6-methyluracil

Conditions
ConditionsYield
In ethanol; water for 24h; Ambient temperature;100%
piperazine
110-85-0

piperazine

5-chloro-2-nitroaniline
1635-61-6

5-chloro-2-nitroaniline

2-nitro-5-piperazin-1-yl-phenylamine
96103-52-5

2-nitro-5-piperazin-1-yl-phenylamine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 24h;100%
for 5h; Heating;93%
With potassium carbonate In N,N-dimethyl acetamide at 120℃; for 21h;84%
piperazine
110-85-0

piperazine

propyl bromide
106-94-5

propyl bromide

1-n-propylpiperazine
21867-64-1

1-n-propylpiperazine

Conditions
ConditionsYield
With triethylamine In ethanol Reflux;100%
With triethylamine In ethanol for 21h; Heating;45%
piperazine
110-85-0

piperazine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1,4-Bis(1'-nitro-3'-(trifluoromethyl)-6'-phenyl)piperazine
137918-81-1

1,4-Bis(1'-nitro-3'-(trifluoromethyl)-6'-phenyl)piperazine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 120h;100%
piperazine
110-85-0

piperazine

C18H18N2O2
80100-67-0

C18H18N2O2

2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one
80100-68-1

2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one

Conditions
ConditionsYield
at 110℃;100%
piperazine
110-85-0

piperazine

Phenyl glycidyl ether
122-60-1

Phenyl glycidyl ether

1-phenoxy-3-(1-piperazinyl)propan-2-ol
40944-05-6

1-phenoxy-3-(1-piperazinyl)propan-2-ol

Conditions
ConditionsYield
In 2,2,2-trifluoroethanol at 20℃; for 6h; regioselective reaction;100%
In ethanol for 0.0583333h; Ring cleavage; addition; Irradiation; microwave irradiation;84%
In methanol at 14.9℃; Rate constant; Thermodynamic data; var. temp., ΔH(excit.), ΔG(excit.), ΔS(excit), E;
piperazine
110-85-0

piperazine

6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
1027017-16-8

6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-o-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

1-o-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid

Conditions
ConditionsYield
In acetonitrile100%
piperazine
110-85-0

piperazine

4,7-dichloroquinoline
86-98-6

4,7-dichloroquinoline

7-chloro-4-piperazinylquinoline
837-52-5

7-chloro-4-piperazinylquinoline

Conditions
ConditionsYield
In isopropyl alcohol at 100℃; for 20h;100%
With triethylamine at 130℃; for 4h; Inert atmosphere;98%
With potassium carbonate In isopropyl alcohol for 36h; Reflux;95%
piperazine
110-85-0

piperazine

carbon monoxide
201230-82-2

carbon monoxide

isopropenylbenzene
98-83-9

isopropenylbenzene

1,4-Bis-(3-phenyl-butyl)-piperazine

1,4-Bis-(3-phenyl-butyl)-piperazine

Conditions
ConditionsYield
With hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer In 1,4-dioxane at 80℃; under 82506.6 Torr; for 72h;100%
piperazine
110-85-0

piperazine

NBD chloride
10199-89-0

NBD chloride

4-nitro-7-(piperazin-1-yl)benzo[c][1,2,5]oxadiazole
139332-66-4

4-nitro-7-(piperazin-1-yl)benzo[c][1,2,5]oxadiazole

Conditions
ConditionsYield
In tetrahydrofuran at 0℃;100%
at 0℃; for 0.833333h;95%
In N,N-dimethyl-formamide at 85℃; for 4h; Inert atmosphere; Schlenk technique;78%
piperazine
110-85-0

piperazine

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
207857-15-6

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

dipiperazine-1,4-carboxamidine

dipiperazine-1,4-carboxamidine

Conditions
ConditionsYield
With triethylamine In chloroform for 20h; Ambient temperature;100%
piperazine
110-85-0

piperazine

benzoyl chloride
98-88-4

benzoyl chloride

2-Methoxybenzoyl chloride
21615-34-9

2-Methoxybenzoyl chloride

N-(2-methoxybenzoyl)-N'-(benzoyl)iperazine

N-(2-methoxybenzoyl)-N'-(benzoyl)iperazine

Conditions
ConditionsYield
Stage #1: piperazine With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Metallation;
Stage #2: benzoyl chloride In tetrahydrofuran for 0.166667h; Acylation;
Stage #3: 2-Methoxybenzoyl chloride In tetrahydrofuran for 0.166667h; Acylation;
100%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

3-(2-isobutylthioethyl)-6-methyluracil
153581-47-6

3-(2-isobutylthioethyl)-6-methyluracil

3-(2-isobutylthioethyl)-6-methyl-5-(piperazin-1-yl)methyluracil

3-(2-isobutylthioethyl)-6-methyl-5-(piperazin-1-yl)methyluracil

Conditions
ConditionsYield
In ethanol; water for 1h; Heating;100%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

5-hydroxy-6-methyluracil
7417-28-9

5-hydroxy-6-methyluracil

5-hydroxy-6-methyl-3-(piperazin-1-yl)methyluracil

5-hydroxy-6-methyl-3-(piperazin-1-yl)methyluracil

Conditions
ConditionsYield
In ethanol; water for 1.08333h; Heating;100%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

5-hydroxy-6-methyluracil
7417-28-9

5-hydroxy-6-methyluracil

5-hydroxy-6-methyl-1,3-bis[(piperazin-1-yl)methyl]uracil

5-hydroxy-6-methyl-1,3-bis[(piperazin-1-yl)methyl]uracil

Conditions
ConditionsYield
In ethanol; water at 50 - 70℃; for 1.16667h;100%
piperazine
110-85-0

piperazine

3-Bromopyridine
626-55-1

3-Bromopyridine

1-(pyridin-3-yl)piperazine
67980-77-2

1-(pyridin-3-yl)piperazine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate In xylene for 4h; Buchwald coupling; Heating;100%
With dichlorobis(tri-O-tolylphosphine)palladium; potassium tert-butylate In diethylene glycol dimethyl ether at 170℃; for 48h;61%
With dichlorobis(tri-O-tolylphosphine)palladium; sodium t-butanolate In various solvent(s) at 169℃; for 24h;32%
piperazine
110-85-0

piperazine

4-chloro-6,7,8-trimethoxy-quinazoline
33371-00-5

4-chloro-6,7,8-trimethoxy-quinazoline

6,7,8-trimethoxy-4-(1-piperazinyl)quinazoline

6,7,8-trimethoxy-4-(1-piperazinyl)quinazoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
Heating;
piperazine
110-85-0

piperazine

4-chloro-6,8-dimethoxyquinazoline
155960-96-6

4-chloro-6,8-dimethoxyquinazoline

6,8-dimethoxy-4-(1-piperazinyl)quinazoline

6,8-dimethoxy-4-(1-piperazinyl)quinazoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
Heating;
piperazine
110-85-0

piperazine

4,6-dichloroquinoline
4203-18-3

4,6-dichloroquinoline

6-chloro-4-(1-piperazinyl)quinoline
92026-62-5

6-chloro-4-(1-piperazinyl)quinoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
piperazine
110-85-0

piperazine

4,8-dichloroquinoline
21617-12-9

4,8-dichloroquinoline

8-chloro-4-(1-piperazinyl)quinoline

8-chloro-4-(1-piperazinyl)quinoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
piperazine
110-85-0

piperazine

4-chloro-6,7-dimethoxycinnoline
7357-26-8

4-chloro-6,7-dimethoxycinnoline

6,7-dimethoxy-4-(1-piperazinyl)cinnoline

6,7-dimethoxy-4-(1-piperazinyl)cinnoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
piperazine
110-85-0

piperazine

4-chloro-7-trifluoromethyl quinoline
346-55-4

4-chloro-7-trifluoromethyl quinoline

4-(piperazin-1-yl)-7-(trifluoromethyl)quinoline

4-(piperazin-1-yl)-7-(trifluoromethyl)quinoline

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
With triethylamine at 80 - 140℃; for 7h;78%
With triethylamine at 80 - 130℃; Neat (no solvent);68%
piperazine
110-85-0

piperazine

1-benzyl-4-chlorophthalazine
40848-53-1

1-benzyl-4-chlorophthalazine

1-(piperazin-1-yl)-4-benzylphthalazine

1-(piperazin-1-yl)-4-benzylphthalazine

Conditions
ConditionsYield
In isopropyl alcohol for 4h; Heating;100%
In ethanol at 20 - 60℃;61%
In ethanol at 60℃; for 5h;61%

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Structural and energetic consequences of replacing one or more carbon atoms in small cyclic hydrocarbons with electronegative atoms have been observed due to stereoelectronic anomeric and gauche effects. We have reported the influence of gauche effect on the conformational behavior of a 1,4-diaz...detailed

110-85-0Relevant articles and documents

Axial ligation of iron(III) porphyrin with a series of aliphatic bases: Piperazine, piperidine and pyrrolidine

Saffari,Khorasani-Motlagh,Noroozifar

, p. 128 - 132 (2012)

The binding of a series of nitrogen donor ligands (Piperazine (Pipz), Piperidine (Pip) and Pyrro- lidine (Pyr)) to iron porphyrin, OEPFeClO 4, where OEP is octaethylporphyrin, has been characterized by electronic spectroscopy in CH2Cl2. In nonaqueous media, in the presence of a neutral ligand, the equilibria observed are: OEPFeClO 4 + 2L [OEPFeL2]+ (β2) where the product is an ion pair and in some cases: OEPFeClO4 + L OEPFeLClO4 (K1), where the product may either be the six-coordinate or the five-coordinate [OEPFeL]+ ion pair, that L denotes neutral N-donor ligands. This behavior for the nitrogen donor ligands (L = Pipz, Pip, Pyr) is confirmed by spectrophotometric titrations data and the bind- ing constants for the substitution reaction have been reported. Pleiades Publishing, Ltd., 2012.

Cobalt-bridged secondary building units in a titanium metal-organic framework catalyze cascade reduction of N-heteroarenes

Feng, Xuanyu,Song, Yang,Chen, Justin S.,Li, Zhe,Chen, Emily Y.,Kaufmann, Michael,Wang, Cheng,Lin, Wenbin

, p. 2193 - 2198 (2019)

We report here a novel Ti3-BPDC metal-organic framework (MOF) constructed from biphenyl-4,4′-dicarboxylate (BPDC) linkers and Ti3(OH)2 secondary building units (SBUs) with permanent porosity and large 1D channels. Ti-OH groups from neighboring SBUs point toward each other with an O-O distance of 2 ?, and upon deprotonation, act as the first bidentate SBU-based ligands to support CoII-hydride species for effective cascade reduction of N-heteroarenes (such as pyridines and quinolines) via sequential dearomative hydroboration and hydrogenation, affording piperidine and 1,2,3,4-tetrahydroquinoline derivatives with excellent activity (turnover number ~ 1980) and chemoselectivity.

Intermolecular condensation of ethylenediamine to 1,4-diazabicyclo[2,2,2]octane over TS-1 catalysts

Wang, Yong,Liu, Yueming,Li, Xiaohong,Wu, Haihong,He, Mingyuan,Wu, Peng

, p. 258 - 267 (2009)

The intermolecular condensation of ethylenediamine (EDA) to 1,4-diazabicyclo[2.2.2]octane or triethylenediamine (TEDA) has been carried out over various titanosilicate catalysts. Superior to Ti-MWW, Ti-Beta, Ti-FER, and Ti-MOR, TS-1 showed higher EDA conversion and TEDA selectivity. The effects of reaction parameters, Ti content, and crystal size on the EDA condensation over TS-1 have been investigated. The mechanism for the TS-1-catalyzed condensation of EDA has also been considered. The acid sites, originated from the Si-OH groups adjacent to the "open" Ti sites, were assumed to contribute to the intermolecular condensation of EDA, whereas the Lewis acid sites directly related to Ti(IV) ions were not the true active sites. The primary intermolecular condensation of EDA to 1,4-diazacyclohexane or piperazine (PIP) took place mainly inside the micropores of the MFI structure, while the secondary condensation of PIP with EDA to TEDA was favored by the acid sites located near the pore entrance and on the outer surface of crystals.

Gas-phase pyrolysis in organic synthesis: A route for synthesis of cyanamides

Al-Awadi, Nouria A.,Abdelkhalik, Mervat Mohammed,El-Dusouqui, Osman M. E.,Elnagdia, Mohammad H.

, p. 207 - 209 (2010)

(Chemical Equation Presented) Pyrolysis of 1,7-di-[(E)-1- morpholinomethylidene]- and 1,7-di-[(E)-1-piperidino-methylidene]-4,6,10,12- tetramethylamino-2,8-dioxo-1,7-diaza-3,5,9,11-cyclododecatetraene-3, 9-dicarbonitrile 6a,b afforded pyridone 10 in addition to cyanamides 11a,b. On the other hand, pyrolysis of 1-[E-(4-(E-3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)- ylimino) methylpiperazin-1-yl] methylenamino-4,6-dimethyl-2-oxo-1,2- dihydropyridine-3-carbonitrile 8 gave 1-amino-4,6-dimethyl-2-oxo-1,2- dihydropyridine-3-carbonitrile 13 as well as piperazine. The mechanism of pyrolysis and the effect of stereochemistry of pyrolyzed substrates on the nature of the pyrolysates are discussed.

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Avar,Kisch

, p. 89,91,95 (1978)

-

Reactivity of borohydride incorporated in coordination polymers toward carbon dioxide

Kadota, Kentaro,Sivaniah, Easan,Horike, Satoshi

, p. 5111 - 5114 (2020)

Borohydride (BH4-)-containing coordination polymers converted CO2into HCO2-or [BH3(OCHO)]-, whose reaction routes were affected by the electronegativity of metal ions and the coo

Palladium supported on magnesium hydroxyl fluoride: An effective acid catalyst for the hydrogenation of imines and N-heterocycles

Agbossou-Niedercorn, Francine,Corre, Yann,Dongare, Mohan K.,Kemnitz, Erhard,Kokane, Reshma,Michon, Christophe,Umbarkar, Shubhangi B.

supporting information, p. 19572 - 19583 (2021/11/04)

Palladium catalysts supported on acidic fluorinated magnesium hydroxide Pd/MgF2-x(OH)x were prepared through precipitation or impregnation methods. Applications to the hydrogenation of various aldimines and ketimines resulted in good catalytic activities at mild temperatures using one atmosphere of hydrogen. Quinolines, pyridines and other N-heterocycles were successfully hydrogenated at higher temperature and hydrogen pressure using low palladium loadings and without the use of any acid additive. Such reactivity trend confirmed the positive effect of the Br?nsted and Lewis acid sites from the fluorinated magnesium hydroxide support resulting in the effective pre-activation of N-heterocycle substrates and therefore in the good catalytic activity of the palladium nanoparticles during the hydrogenations. As demonstrated in the hydrogenation of imines, the catalyst was recycled up to 10 times without either loss of activity or palladium leaching. This journal is

Catalytic reduction of aromatic ring in aqueous medium

-

Page/Page column 10; 16, (2020/05/04)

A method of reducing an aromatic ring under relatively mild condition using sub-nano particles of a transition metal supported on super paramagnetic iron oxide nanoparticles (SPIONs). The catalyst is efficient for catalyzing the reduction of both carbocyclic and heterocyclic compound. In compound comprising both carbocyclic and heterocyclic aromatic rings, the catalyst displays high regioselectivity for the heterocyclic ring.

METHOD FOR PRODUCING ETHANOLAMINES AND/OR ETHYLENEAMINES

-

Paragraph 0250-0257, (2020/04/09)

The present invention relates to a process for preparing ethanolamines and/or ethyleneamines in the gas phase by reacting ethylene glycol with ammonia in the presence of an amination catalyst. It is a characteristic feature of the process that the amination catalyst is prepared by reducing a calcined catalyst precursor comprising an active composition, where the active composition comprises one or more active metals selected from the group consisting of the elements of groups 8, 9, 10 and 11 of the Periodic Table of the Elements and optionally one or more added catalyst elements selected group consisting of the metals and semimetals of groups 3 to 7 and 12 to 17, the element P and the rare earth elements. It is a further characteristic feature of the process that a catalyst precursor having low basicity is used, the low basicity being achieved in that a) the catalyst precursor is prepared by coprecipitation and the active composition additionally comprises one or more basic elements selected from the group consisting of the alkali metals and alkaline earth metals; orb) the catalyst precursor, as well as the active composition, additionally comprises a support material and is prepared by impregnating the support material or precipitative application onto the support material and the support material comprises one or more basic elements selected from the group consisting of the alkali metals, Be, Ca, Ba and Sr or one or more minerals selected from the group consisting of hydrotalcite, chrysotile and sepiolite; orc) the catalyst precursor, as well as the active composition, additionally comprises a support material and is prepared by impregnating the support material or precipitative application onto the support material and the active composition of the catalyst support comprises one or more basic elements selected from the group consisting of the alkali metals and the alkaline earth metals; ord) the catalyst precursor is calcined at temperatures of 600° C. or more; ore) the catalyst precursor is prepared by a combination of variants a) and d) or by a combination of variants b) and d) or by a combination of variants c) and d).

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