110042-95-0 Usage
Description
Acemannan Hydrogel was marketed in the US as a wound healing agent for the care of
ulcers, burns and post-surgical incisions. Acemannan is a complex water soluble polymanno-
galacto acetate isolated from Aloe vera by alcohol precipitation and purified by
filtration to limit the size of the polysaccharide polymers. Pharmacological studies
demonstrated immunostimulatory activity through the activation of monocytes and
macrophages triggering enhanced secretion of cytokines such as interferon, interleukins,
TNF-alpha, GM-CSF and some prostaglandins. It was proposed that the adjuvant activity
of this agent could be partly related to its ability to induce phenotypic and functional
maturation of immature dendritic cells. In normal healthy males, acemannan administered
orally up to 3200 mg/day for 6 days did not show any acute oral toxicity. Acemannan is
currently undergoing clinical trials for the treatment of AIDS.
Originator
Carrington Laboratories (US)
Uses
Different sources of media describe the Uses of 110042-95-0 differently. You can refer to the following data:
1. Antiviral; immunomodulator.
2. Acemannan is an polysaccharide found in the leaves of Aloe Vera (Aloe barbadensis Miller) plant, and is used in a variety of Aloe Vera products.
Brand name
Carraklenz Wound &Skin Cleanser (Carrington); Carrisyn (Carrington); Snow &
Sun Sports Gel (Carrington).
Veterinary Drugs and Treatments
Veterinary acemannan injection is labeled for use in dogs or cats as
an aid in the treatment (i.e., surgery) and clinical management of
fibrosarcoma. It has been used to treat FeLV, FIV, and FIP infections
in cats but clinical efficacy has not been adequately proven by controlled
clinical studies. It reportedly has been used in horses, but no
specific information on this was located.
Check Digit Verification of cas no
The CAS Registry Mumber 110042-95-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,0,4 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 110042-95:
(8*1)+(7*1)+(6*0)+(5*0)+(4*4)+(3*2)+(2*9)+(1*5)=60
60 % 10 = 0
So 110042-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C66H101NO49/c1-18(75)67-33-34(83)42(26(11-68)102-59(33)110-44-29(14-71)106-63(38(87)51(44)97-21(4)78)113-46-30(15-72)107-64(39(88)53(46)99-23(6)80)111-45-28(13-70)103-60(94-10)35(84)50(45)96-20(3)77)109-61-37(86)52(98-22(5)79)48(32(17-74)105-61)114-66-41(90)55(101-25(8)82)56(57(116-66)58(91)92)115-65-40(89)54(100-24(7)81)47(31(16-73)108-65)112-62-36(85)49(95-19(2)76)43(93-9)27(12-69)104-62/h26-57,59-66,68-74,83-90H,11-17H2,1-10H3,(H,67,75)(H,91,92)/p-1/t26-,27-,28-,29-,30-,31-,32-,33+,34-,35+,36+,37+,38+,39+,40+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56+,57+,59-,60+,61-,62-,63-,64-,65-,66+/m1/s1
