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11006-90-9

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11006-90-9 Usage

General Description

Edeine is a peptide antibiotic derived from the bacterium Bacillus brevis that is known for its ability to inhibit protein synthesis. It works by binding to the 50S subunit of bacterial ribosomes, preventing the elongation of peptide chains and ultimately leading to the inhibition of bacterial growth. Edeine has been studied for its potential use in the treatment of infectious diseases caused by various bacteria, and its molecular structure has been essential in understanding the mechanisms of protein synthesis in bacteria. While it has shown promise as an antibiotic, further research is needed to fully understand its potential applications and to address any potential resistance development.

Check Digit Verification of cas no

The CAS Registry Mumber 11006-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,0 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 11006-90:
(7*1)+(6*1)+(5*0)+(4*0)+(3*6)+(2*9)+(1*0)=49
49 % 10 = 9
So 11006-90-9 is a valid CAS Registry Number.

11006-90-9Upstream product

11006-90-9Downstream Products

11006-90-9Related news

On the mode of action of Edeine (cas 11006-90-9): II. Studies on the binding of Edeine (cas 11006-90-9) to Escherichia coli ribosomes08/21/2019

Edeine binds to 70-S ribosomes in the presence of 10 mM MgCl2. At a concentration of Mg2+ of 1 mM the binding is 30 times greater than at 10 mM. Edeine does not affect the formation of polysomes, although some binding of edeine to polysomes is observed. Edeine causes association of 30-S and 50-S...detailed

Biosynthesis of Edeine (cas 11006-90-9): Fractionation and characterization of enzymes responsible for biosynthesis of Edeine (cas 11006-90-9) A and B08/20/2019

Enzymes obtained from cells disrupted by lysozyme treatment were resolved into three complementary enzyme fractions by DEAE-cellulose-Sephadex G-200 chromatography. These enzymes of molecular weight 210 000 (A), 180 000 (B) and 100 000 (C) were responsible for the activation of the constituent a...detailed

[42] Edeine (cas 11006-90-9) synthetase08/19/2019

Publisher SummaryThis chapter discusses the assay and purification procedure of edeine synthetases. In assay method, binding of the amino acyl to the enzyme complex can be measured only if radioactive edeine constituent amino acids are available. Formation of edeine A and B is measured by incorp...detailed

On the mode of action of Edeine (cas 11006-90-9) effect of Edeine (cas 11006-90-9) on the bacterial DNA08/17/2019

Edeine inhibits the synthesis of bacterial DNA as shown by the incorporation studies of [3H]thymidine into DNA of Escherichia coli 15 T−. It does not induce a release of [3H]thymidine from prelabeled DNA. Edeine does not bind to the DNA. DNA isolated from edeine treated Bacillus subtilis shows t...detailed

Inactive form of Edeine (cas 11006-90-9) in the Edeine (cas 11006-90-9)-producing Bacillus brevis Vm 4 cells08/16/2019

1.1. Exogenous edeine inhibits the synthesis of DNA and protein, but not that of RNA, in extracts of edeine-producing Bacillus brevis Vm 4 cells. This is analogous to the effect of edeine on extracts obtained from edeine-sensitive cells.2.2. Producer cells, in contrast to sensitive ones, are not...detailed

ArticleDissecting the Ribosomal Inhibition Mechanisms of Edeine (cas 11006-90-9) and Pactamycin: The Universally Conserved Residues G693 and C795 Regulate P-Site RNA Binding08/15/2019

The crystal structures of the universal translation-initiation inhibitors edeine and pactamycin bound to ribosomal 30S subunit have revealed that edeine induces base pairing of G693:C795, residues that constitute the pactamycin binding site. Here, we show that base pair formation by addition of ...detailed

ArticleSelf Resistance to the Atypical Cationic Antimicrobial Peptide Edeine (cas 11006-90-9) of Brevibacillus brevis Vm4 by the N-Acetyltransferase EdeQ08/14/2019

SummaryEdeines are atypical cationic peptides produced by Brevibacillus brevis Vm4 with broad-spectrum antimicrobial activity. These linear nonribosomal peptides bind to the 30S ribosomal subunit and block t-RNA binding to the P-site. To identify the mechanism of high-level self-resistance in th...detailed

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