110851-56-4Relevant articles and documents
A short synthesis of 2-vinylinosine
Zhang, Han-Zhong,Fried, Josef
, p. 351 - 355 (1996)
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IMPDH as a biological probe for RNA antiviral drug discovery: Synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases
Nair, Vasu,Ma, Xiaohui,Shu, Qingning,Zhang, Fan,Uchil, Vinod,Cherukupalli, Govardhan R.
, p. 651 - 654 (2007)
Our interest in the discovery of molecules with antiviral activity against RNA viruses led us to the design of ribonucleosides with surrogate bases with the intent of using inhibition of inosine monophosphate dehydrogenase (IMPDH) as a probe for antiviral drug discovery. A general methodology for the preparation of these compounds is discussed. Kinetic parameters of the inhibition studies with IMPDH, which were carried out spectrophotometrically by monitoring the formation of NADH, are given. Antiviral information and correlation of activity with IMPDH inhibition are discussed. Copyright Taylor & Francis Group, LLC.
Novel approaches to functionalized nucleosides via palladium-catalyzed cross coupling with organostannanes
Nair,Turner,Chamberlain
, p. 7223 - 7224 (1987)
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