111249-52-6Relevant articles and documents
Synthesis of novel 2-cyanothiazolocarbazoles analogues of ellipticine
Chabane, Hadjila,Lamazzi, Christelle,Thiéry, Valérie,Guillaumet, Gérald,Besson, Thierry
, p. 2483 - 2486 (2002)
Novel linear thiazolocarbazoles, which are structurally very close to the natural alkaloid ellipticine, have been rapidly synthesised via imino-1,2,3-dithiazoles, themselves readily obtained by treatment of the appropriate 3-aminocarbazoles with 4,5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt).
Etude de la cytotoxicite in vitro de derives du carbazole III. 3-Amino et 3-nitro-1,4-dimethyl-9H-carbazoles diversement substitutes en position 6
Letois, B,Lancelot, J C,Rault, S,Robba, M,Tabka, T,et al.
, p. 775 - 784 (2007/10/02)
The synthesis of a series of nitro and amino-1,4-dimethyl-9H-carbazoles is described.The cytotoxic activities, as assayed in vitro using clonogenic cell culture of murine leukemia L1210, vary greatly with the nature and position of substituents.The most cytotoxic derivatives, 3-amino-6-hydroxy 1,4-dimethyl-9H-carbazole, displays an activity similar to that of N2-methyl-9-hydroxy ellipticinium acetate (NMHE).These results, together with those previously published by us, allow a detailed analysis of structure-activity relationships in the 9H-carbazole and1,4-dimethyl-9H-carbazole series.For the 3-amino-1,4-dimethyl 9H-carbazole derivatives, a mechanism of action similar to that of ellipticine derivatives is proposed.
