111249-53-7 Usage
Chemical class
Carbazole derivative
Molecular structure
Complex, with a fused pyrido and carbazole ring system
Keto group (C=O)
Indicates the presence of a carbonyl group
Aromatic rings
Consists of multiple aromatic rings in the structure
Methyl groups (-CH3)
Three methyl groups are present at positions 2, 5, and 11
Applications
Pharmaceutical research and drug development
Anti-inflammatory
Potential to reduce inflammation
Antitumor
Potential to inhibit tumor growth
Antioxidant
Potential to neutralize harmful free radicals
Research status
Further research is needed to fully understand its potential applications and effects
Check Digit Verification of cas no
The CAS Registry Mumber 111249-53-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,2,4 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 111249-53:
(8*1)+(7*1)+(6*1)+(5*2)+(4*4)+(3*9)+(2*5)+(1*3)=87
87 % 10 = 7
So 111249-53-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H16N2O/c1-9-8-14(21)16-11(3)17-15(10(2)18(16)19-9)12-6-4-5-7-13(12)20-17/h4-8,20H,1-3H3,(H,19,21)
111249-53-7Relevant articles and documents
Structural study of an analog of ellipticine designed as antineoplastic, 1,4-dihydro-4-oxo-2,5,11-trimethyl-6H-pyrido[3,2-b]carbazole, with X-ray diffraction
Viossat,Dung,Lancelot,Benazeth,Rault,Robba
, p. 1724 - 1733 (1987)
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In vitro cytotoxicity of carbazole derivatives IV. 5.11-Dimethyl-6H-pyridocarbazoles substituted on the pyridine ring
Moinet-Hedin, V.,Tabka, T.,Gauduchon, P.,Talaer, J. Y. Le,Letois, B.,et al.
, p. 721 - 726 (2007/10/02)
A series of 5,11-dimethyl-6H-pyridocarbazoles, structurally related to the antitumor drug ellipticine, were synthesized from 3-amino-1,4-dimethyl-9H-carbazole.Among 17 derivatives, bearing various substituents on the pyridine ring, and preliminarily evaluated for cytotoxicity on L1210-cultured cells, 13 (76percent) were found to be active.One of them, 5,11-dimethyl-4-ethoxy-6H-pyridocarbazole, although non-substituted on C-9, displayed an activity similar to that of 9-hydroxy-N-2-methyl-ellipticinium acetate.Structure-activity relationships have been described in detail. cytotoxicity/leukemia L1210/clonogenic assay/pyridocarbazoles
