111511-90-1Relevant articles and documents
Water-soluble third generation antitumor platinum complexes, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][1,1-cyclobutanedicarboxylato(2- )-O,O']platinum(II) and [1,1-cyclobutanedicarboxylato(2-)-O,O'][tetrahydro-4H-pyran-4,4- dimethanamine-N,N']platinum(II)
Bitha,Carvajal,Citarella,Child,Delos Santos,Dunne,Durr,Hlavka,Lang Jr.,Lindsay,Morton,Thomas,Wallace,Lin,Haltiwanger,Pierpont
, p. 2015 - 2020 (1989)
The synthesis, stability, and antitumor activity of a series of water-soluble third generation platinum(II) complexes have been described. Among these complexes, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][1,1-cyclobutanedicarboxylato(2- )-O,O']platinum(II) and [1,1-cyclobutanedicarboxylato(2-)-O,O'](tetrahydro-4H-pyran-4,4- dimethanamine-N,N')platinum(II) have shown the greatest promise for further investigation and are currently under clinical evaluation.
PHENYL-HETEROARYL AMINE COMPOUNDS AND THEIR USES
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Page/Page column 81, (2012/06/01)
The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I, and pharmaceutical compositions comprising such compounds
N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES
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Page/Page column 118, (2012/08/08)
The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.
