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111525-02-1

111525-02-1

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111525-02-1 Usage

General Description

N-(1-naphthalen-2-yl-ethyl)-hydroxylamine, also known as NNEHA, is a chemical compound primarily used as a reagent in organic synthesis. It is a hydroxylamine derivative with a naphthalene group attached to an ethyl chain. NNEHA has been studied for its potential use in the prevention and treatment of oxidative stress-related diseases and as a reagent in the synthesis of organic compounds. It has also been explored as a potential therapeutic agent for its anti-inflammatory and antioxidant properties. However, further research is necessary to fully understand its potential applications and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 111525-02-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,5,2 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 111525-02:
(8*1)+(7*1)+(6*1)+(5*5)+(4*2)+(3*5)+(2*0)+(1*2)=71
71 % 10 = 1
So 111525-02-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H13NO/c1-9(13-14)11-7-6-10-4-2-3-5-12(10)8-11/h2-9,13-14H,1H3

111525-02-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(1-naphthalen-2-ylethyl)hydroxylamine

1.2 Other means of identification

Product number -
Other names N-(1-Naphthalen-2-yl-ethyl)-hydroxylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:111525-02-1 SDS

111525-02-1Upstream product

111525-02-1Downstream Products

111525-02-1Relevant articles and documents

Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors

Stewart, Andrew O.,Bhatia, Pramila A.,Martin, Jonathan G.,Summers, James B.,Rodriques, Karen E.,Martin, Michael B.,Holms, James H.,Moore, Jimmie L.,Craig, Richard A.,Kolasa, Teodozyj,Ratajczyk, James D.,Mazdiyasni, Hormoz,Kerdesky, Francis A. J.,DeNinno, Shari L.,Maki, Robert G.,Bouska, Jennifer B.,Young, Patrick R.,Lanni, Carmine,Bell, Randy L.,Carter, George W.,Brooks, Clint D. W.

, p. 1955 - 1968 (2007/10/03)

The discovery of second generation N-hydroxyurea 5-lipoxygenase inhibitors was accomplished through the development of a broad structure- activity relationship (SAR) study. This study identified requirements for improving potency and also extending duration by limiting metabolism. Potency could be maintained by the incorporation of heterocyclic templates substituted with selected lipophilic substituents. Duration of inhibition after oral administration was optimized by identification of structural features in the proximity of the N-hydroxyurea which correlated to low in vitro glucuronidation rates. Furthermore, the rate of in vitro glucuronidation was shown to be stereoselective for certain analogs. (R)-N- [3-[5-(4-Fluorophenoxy)-2-furyl]-1-methyl-2-propynyl]-N-hydroxyurea (17c) was identified and selected for clinical development.

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