114059-99-3Relevant articles and documents
Hydroxylation of Alkyl Halides with Water in Ionic Liquid: Significantly Enhanced Nucleophilicity of Water
Kim, Dong Wook,Hong, Dong Jin,Seo, Jai Woong,Kim, Hoon Sik,Kim, Hong Kon,Song, Choong Eui,Chi, Dae Yoon
, p. 3186 - 3189 (2004)
A facile method for the nucleophilic hydroxylation of alkyl halides and mesylates with water has been developed in which the use of ionic liquid as an alternative reaction medium not only enhanced the nucleophilicity of water but also reduced the formation of elimination products predominantly formed under the conventional basic reaction conditions. For example, hydroxylation of model compound 2-(3-bromopropyl)naphthalene (1) to 2-(3-hydroxypropyl)-naphthalene (2) with water in 1-n-butyl-3-methylimidazolium tetrafluoroborate ([bmim] [BF 4]) and 1,4-dioxane proceeded selectively in high yield (94%). The reactivity of other nucleophilic oxygen sources such as alcohol, phenol, and acetic acid in an ionic liquid was also investigated.
Preparation method of pyridine quinazoline intermediate (by machine translation)
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Paragraph 0010-0011; 0015-0016; 0020-0021; 0025-0026; 0030, (2020/11/02)
N - alkylation reaction is firstly carried out on 3 - (hydrazinomethyl) pyridine and 2 - (chloromethyl) aniline followed by benzene ring substitution reaction to obtain 6 - (perfluoropropane -2 - yl) -3 - ((pyridin -3 - methylene) amino) -3 and 4 -dihydroquinazoline -2 (1H)-one. In this route, 2 - methylaniline benzyl chloride reaction is many, the design is carried out in the preceding step, 2 - (chloromethyl) aniline is subjected to high vacuum rectification, 95.0-97 .0% is reached, and impurities in subsequent reactions are reduced. In addition, the expensive raw material 2 - bromoheptafluoropropane is reacted in the following step, the raw material cost is reduced, and the total yield is 72.0-74 .0% (in 2 - bromoheptafluoropropane). (by machine translation)
