114080-93-2Relevant articles and documents
A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives
Yu, Wensheng,Bulger, Paul G.,Maloney, Kevin M.
, p. 4941 - 4946 (2016/10/12)
A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.
Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation
Hong, Yong Rae,Kim, Hyun Tae,Ro, Seonggu,Cho, Joong Myung,Lee, Sang Hwi,Kim, In Su,Jung, Young Hoon
, p. 3142 - 3145 (2015/02/19)
The design, synthesis, and capacity to inhibit HIF prolyl 4-hydroxylases (PHDs) are described for 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide analogs. These analogs revealed two kinds of novel scaffolds as PHD2 inhibitors. Synthetic routes were
Design, synthesis and evaluation of new α-nucleophiles for the hydrolysis of organophosphorus nerve agents: Application to the reactivation of phosphorylated acetylcholinesterase
Saint-Andre, Geraldine,Kliachyna, Maria,Kodepelly, Sanjeevarao,Louise-Leriche, Ludivine,Gillon, Emilie,Renard, Pierre-Yves,Nachon, Florian,Baati, Rachid,Wagner, Alain
scheme or table, p. 6352 - 6361 (2011/09/19)
A series of new α-nucleophiles including oximes and amidoximes have been synthesized, and their ability to efficiently and selectively cleave the P-S bond of organophosphorus nerve agents has been evaluated. The relationship between the chemical structure
