1141-23-7

• 

• Basic information

  1. Product Name: 3-(4-Chlorophenyl)glutaramic acid
  2. Synonyms: -(4-Chlorophenyl)glutaricacidmonoamide;B-(4-CHLOROPHENYL) GLUTARIC ACID MONOAMIDE;3-(4-CHLOROPHENYL)GLUTARAMIC ACID;3-(4-CHLOROPHENYL)GLUTARIC ACID MONOAMIDE;beta-(4-Chlorophenyl)glutaric acid monoamide;3-(4-Chlorophenyl)Glutaramic Acid Monoamide;4-Carbamoyl-3-(4-chlorophenyl)butanoic Acid;5-AMino-3-(4-chlorophenyl)-5-oxopentanoic acid
  3. CAS NO:1141-23-7
  4. Molecular Formula: C₁₁H₁₂ClNO₃
  5. Molecular Weight: 241.67
  6. EINECS: N/A
  7. Product Categories: Organic acids
  8. Mol File: 1141-23-7.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: 168-170°C
  2. Boiling Point: 494.898 °C at 760 mmHg
  3. Flash Point: 253.106 °C
  4. Appearance: /
  5. Density: 1.343 g/cm³
  6. Vapor Pressure: 1.3E-10mmHg at 25°C
  7. Refractive Index: 1.578
  8. Storage Temp.: Sealed in dry,Room Temperature
  9. Solubility: Methanol (Slightly)
  10. BRN: 2460842
  11. CAS DataBase Reference: 3-(4-Chlorophenyl)glutaramic acid(CAS DataBase Reference)
  12. NIST Chemistry Reference: 3-(4-Chlorophenyl)glutaramic acid(1141-23-7)
  13. EPA Substance Registry System: 3-(4-Chlorophenyl)glutaramic acid(1141-23-7)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: 36/37/38
  3. Safety Statements: 26-36
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 1141-23-7(Hazardous Substances Data)

• Suppliers
• Usage
• Well-known Company Product Price
• SDS
• Synthetic route
• Upstream product
• Downstream Products
• Article

1141-23-7 Suppliers

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• 3-(4-Chlorophenyl)glutaramic acid Manufacturer/High quality/Best price/In stock

  Cas No: 1141-23-7

• USD $ 3.0-3.0 / Kilogram

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• High quality Β-(4-Chlorophenyl)Glutarimide supplier in China

  Cas No: 1141-23-7

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• Simagchem Corporation
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• β-(4-chlorophenyl)Glutarimide from China

  Cas No: 1141-23-7

• USD $ 2.0-3.0 / Kilogram

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• Factory Supply 5-amino-3-(4-chlorophenyl)-5-oxopentanoic acid

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• Ality Chemical Corporation
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• 3-(4-Chlorophenyl)-glutaramic acid

  Cas No: 1141-23-7

• USD $ 1.2-5.0 / Kiloliter

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• 3-(4-Chlorophenyl)glutaramic acid

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• Hebei Nengqian Chemical Import and Export Co., LTD
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• Factory direct supply CAS 1141-23-7 with best quality

  Cas No: 1141-23-7

• USD $ 139.0-210.0 / Kilogram

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• Zhuozhou Wenxi import and Export Co., Ltd
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• Cheap Price Ready Stock 3-(4-Chlorophenyl)glutaramic acid

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• Benzenepropanoic acid, b-(2-amino-2-oxoethyl)-4-chloro- 1141-23-7

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1141-23-7 Usage

Uses

3-(4-Chlorophenyl)glutaramic acids serves as a reagent for the synthesis of heterocyclic compounds as mGlu5 antagonists for treating urinary tract disorders, migraine, and gastroesophageal reflux disease.

Check Digit Verification of cas no

The CAS Registry Mumber 1141-23-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1141-23:
(6*1)+(5*1)+(4*4)+(3*1)+(2*2)+(1*3)=37
37 % 10 = 7
So 1141-23-7 is a valid CAS Registry Number.

InChI:InChI=1/C11H12ClNO3/c12-9-3-1-7(2-4-9)8(5-10(13)14)6-11(15)16/h1-4,8H,5-6H2,(H2,13,14)(H,15,16)

1141-23-7 Well-known Company Product Price

• Brand
• (Code)Product description
• CAS number
• Packaging
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• Detail

• Alfa Aesar

• (L18692)  3-(4-Chlorophenyl)glutaramic acid, 97%   

• 1141-23-7

• 5g

• 441.0CNY

• Detail

• Alfa Aesar

• (L18692)  3-(4-Chlorophenyl)glutaramic acid, 97%   

• 1141-23-7

• 25g

• 1590.0CNY

• Detail

1141-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	3-(4-Chlorophenyl)Glutaramic Acid

1.2 Other means of identification

Product number	-
Other names	Baclofen Impurity B

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1141-23-7 SDS

1141-23-7Synthetic route

84803-46-3

4-(4-chlorophenyl)piperidine-2,6-dione

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 65 - 70℃; for 1.5h;	89.5%

104-88-1

4-chlorobenzaldehyde

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: diammonium phosphate / water / 5 h / 15 - 20 °C 2: potassium hydroxide / 2 h / 85 - 90 °C 3: urea / 1 h / 130 - 140 °C 4: sodium hydroxide / water / 1.5 h / 65 - 70 °C View Scheme
Multi-step reaction with 3 steps 1: pyridine; piperidine / 12 h / Reflux 2: potassium carbonate; dihydrogen peroxide / methanol; dimethyl sulfoxide; water / 0 °C 3: hydrogenchloride / water / 95 °C View Scheme

19411-80-4

2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydroxide / 2 h / 85 - 90 °C 2: urea / 1 h / 130 - 140 °C 3: sodium hydroxide / water / 1.5 h / 65 - 70 °C View Scheme

35271-74-0

3-(4-chlorophenyl)pentane-1,5-dioic acid

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: urea / 1 h / 130 - 140 °C 2: sodium hydroxide / water / 1.5 h / 65 - 70 °C View Scheme

3-(p-chlorophenyl)-glutaramide

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
With hydrogenchloride In water at 95℃;

3-(4′-chlorophenyl)glutaronitrile

1141-23-7

3-(p-chlorophenyl)glutaramic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate; dihydrogen peroxide / methanol; dimethyl sulfoxide; water / 0 °C 2: hydrogenchloride / water / 95 °C View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions

Conditions	Yield
With sodium sulfamate; sodium hypobromide at -5 - 55℃; for 2.16667h;	79.4%

2627-86-3

(S)-1-phenyl-ethylamine

1141-23-7

3-(p-chlorophenyl)glutaramic acid

A

(R)-4-Carbamoyl-3-(4-chloro-phenyl)-butyric acid; compound with (S)-1-phenyl-ethylamine

B

(S)-4-Carbamoyl-3-(4-chloro-phenyl)-butyric acid; compound with (S)-1-phenyl-ethylamine

Conditions

Conditions	Yield
In methanol at 60℃;	A 73% B 53%

2627-86-3

(S)-1-phenyl-ethylamine

1141-23-7

3-(p-chlorophenyl)glutaramic acid

(R)-4-Carbamoyl-3-(4-chloro-phenyl)-butyric acid; compound with (S)-1-phenyl-ethylamine

Conditions

Conditions	Yield
In methanol at 60 - 65℃;	40%

1141-23-7

3-(p-chlorophenyl)glutaramic acid

100-39-0

benzyl bromide

benzyl 4-carbamoyl-3-(4-chlorophenyl)butanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	91 mg

1141-23-7

3-(p-chlorophenyl)glutaramic acid

69308-37-8

(R)-baclofen

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

63701-55-3

(R)-(-)-baclofen hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4: hydrogenchloride / ethyl acetate / 1 h View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

(R)-baclofen cinnamic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4: acetone / 15 h / 15 - 25 °C View Scheme
Multi-step reaction with 5 steps 1.1: methanol / 60 - 65 °C 2.1: sodium hydroxide / water / 20 - 25 °C 3.1: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4.1: hydrogenchloride / ethyl acetate / 1 h 5.1: ammonia / water; methanol / pH 6.5-7 5.2: 15 h / 15 - 25 °C View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

(R)-baclofen salicyclic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4: tert-butyl methyl ether / 15 h / 15 - 25 °C View Scheme
Multi-step reaction with 5 steps 1.1: methanol / 60 - 65 °C 2.1: sodium hydroxide / water / 20 - 25 °C 3.1: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4.1: hydrogenchloride / ethyl acetate / 1 h 5.1: ammonia / water; methanol / pH 6.5-7 5.2: 15 h / 15 - 25 °C View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

(R)-baclofen ferulic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4: water; acetone / 15 h / 15 - 25 °C View Scheme
Multi-step reaction with 5 steps 1.1: methanol / 60 - 65 °C 2.1: sodium hydroxide / water / 20 - 25 °C 3.1: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4.1: hydrogenchloride / ethyl acetate / 1 h 5.1: ammonia / water; acetone / pH 6.5-7 5.2: 15 h / 15 - 25 °C View Scheme

1141-23-7

3-(p-chlorophenyl)glutaramic acid

(R)-baclofen benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: methanol / 60 - 65 °C 2: sodium hydroxide / water / 20 - 25 °C 3: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4: 15 h / 15 - 25 °C View Scheme
Multi-step reaction with 5 steps 1.1: methanol / 60 - 65 °C 2.1: sodium hydroxide / water / 20 - 25 °C 3.1: sodium hydroxide; sodium hypochlorite / water / 6 h / 0 - 40 °C 4.1: hydrogenchloride / ethyl acetate / 1 h 5.1: ammonia / water; methanol / pH 6.5-7 5.2: 15 h / 15 - 25 °C View Scheme

1141-23-7Upstream product

• 35271-74-0 3-(4-chlorophenyl)pentane-1,5-dioic acid 
• 19411-80-4 2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 84803-46-3 4-(4-chlorophenyl)piperidine-2,6-dione 

1141-23-7Downstream Products

• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 69308-37-8 (R)-baclofen 

1141-23-7Relevant articles and documents

Biocatalytic Desymmetrization of Prochiral 3-Aryl and 3-Arylmethyl Glutaramides: Different Remote Substituent Effect on Catalytic Efficiency and Enantioselectivity

Ao, Yu-Fei,Zhang, Li-Bin,Wang, Qi-Qiang,Wang, De-Xian,Wang, Mei-Xiang

, p. 4594 - 4603 (2018/10/31)

Catalyzed by an amidase-containing Rhodococcus erythropolis AJ270 microbial whole cell catalyst in neutral phosphate buffer at 30 °C, desymmetric hydrolysis of a series of prochiral 3-aryl and 3-arylmethylglutaramides efficiently afforded 3-substituted glutaric acid monoamides in up to 95% yield and >99.5% ee. Even far away from the reaction site, the substituents on the aryl still have a significant effect on the catalytic activity and enantioselectivity and different remote substituent effect was observed for the two types of substrates. The synthetic application of biocatalytic desymmetrization was demonstrated by the facile transformation of the obtained enantiopure (R)-3-substituted 4-carbamoylbutanoic acid products to chiral dihydroquinolinone and δ-lactone compounds. (Figure presented.).

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