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114636-33-8

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114636-33-8 Usage

General Description

(R)-(+)-Benzyl-3-acetylaminopyrrolidine is a chemical compound that is commonly used in pharmaceutical research and development. It is a derivative of pyrrolidine and contains a benzyl group, an acetyl group, and an amino group. (R)-(+)-BENZYL-3-ACETYLAMINOPYRROLIDINE& has potential applications in the synthesis of pharmaceutical drugs and as a building block for the creation of new chemical entities. Its stereochemistry and functional groups make it a valuable intermediate in the production of bioactive molecules and could potentially be used in the development of new drugs for various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 114636-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,3 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114636-33:
(8*1)+(7*1)+(6*4)+(5*6)+(4*3)+(3*6)+(2*3)+(1*3)=108
108 % 10 = 8
So 114636-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O/c1-11(16)14-13-7-8-15(10-13)9-12-5-3-2-4-6-12/h2-6,13H,7-10H2,1H3,(H,14,16)/t13-/m1/s1

114636-33-8 Well-known Company Product Price

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  • Aldrich

  • (536628)  (R)-(+)-1-Benzyl-3-acetylaminopyrrolidine  97%

  • 114636-33-8

  • 536628-1G

  • 2,211.30CNY

  • Detail

114636-33-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[(3R)-1-benzylpyrrolidin-3-yl]acetamide

1.2 Other means of identification

Product number -
Other names (R)-(+)-1-Benzyl-3-acetylaminopyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114636-33-8 SDS

114636-33-8Relevant articles and documents

Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

Chough, Chieyeon,Joung, Misuk,Lee, Sunmin,Lee, Jaemin,Kim, Jong Hoon,Kim, B. Moon

, p. 1495 - 1510 (2018/02/19)

A series of 3(R)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib's core structure, (3R,4R)-3-amino-4-methylpiperidine. From the new core structures, we selected (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (R)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (6) was chosen for further in vivo test through oral administration. Compound 6 showed improved selectivity for JAK1 compared to that of tofacitinib (IC50 11, 2.4 × 102, 2.8 × 103, and 1.1 × 102 nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound 6 exhibited similar efficacy to tofacitinib citrate.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

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Page/Page column 23, (2009/07/17)

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

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