114781-19-0 Usage
Description
(S)-2-AMINO-2-ETHYLOCTANOIC ACID, also known as etilefrine, is a synthetic compound belonging to the class of amino acid derivatives. It is a derivative of phenylephrine and possesses pharmacological properties that make it a valuable agent in the medical field.
Uses
Used in the Medical Industry:
(S)-2-AMINO-2-ETHYLOCTANOIC ACID is used as a sympathomimetic drug for treating conditions such as hypotension and orthostatic hypotension. As a selective alpha-1 adrenergic receptor agonist, it promotes vasoconstriction and raises blood pressure, making it effective in managing shock, orthostatic hypotension, and low blood pressure during anesthesia or surgery.
Additionally, (S)-2-AMINO-2-ETHYLOCTANOIC ACID is used as a treatment for urinary incontinence, providing relief to patients suffering from this condition. It is available in both oral and injectable forms, offering flexibility in administration and catering to various medical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 114781-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,8 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 114781-19:
(8*1)+(7*1)+(6*4)+(5*7)+(4*8)+(3*1)+(2*1)+(1*9)=120
120 % 10 = 0
So 114781-19-0 is a valid CAS Registry Number.
114781-19-0Relevant articles and documents
Chemo-Enzymic Synthesis of Optically Active α,α-Disubstituted α-Amino Acids
Liu, Weiguo,Ray, Paul,Benezra, Steven A.
, p. 553 - 560 (2007/10/02)
A series of α,α-disubstituted α-amino esters was chemically synthesized and then resolved through enantioselective hydrolysis catalysed by a new enzyme isolated from crude Humicola langinosa lipase.This enzyme only accepts free amino esters as substrates with neither lipase activity toward olive oil nor esterase activity toward o-nitrophenyl butyrate.It is unique in that it successfully catalyses the resolution of amino esters with two large α-alkyl groups including aliphatic, aromatic and cyclic amino esters.Examples of resolutions where the alkyl groups differ in size by as little as a single carbon atom have been demonstrated.For determination of absolute configuration, some of the optically active α,α-disubstituted amino acids were also prepared through Schoellkopf's asymmetric synthesis and the structures were verified by X-ray crystallography.A model depicting the substrate binding site of the enzyme is proposed.
