114880-33-0Relevant articles and documents
Sandwich immunoassay as a high-throughput screening method for cross-coupling reactions
Vicennati, Paola,Bensel, Nicolas,Wagner, Alain,Creminon, Christophe,Taran, Frederic
, p. 6863 - 6866 (2005)
Catalyst sandwich: An efficient and sensitive high-throughput-screening method that uses sandwich immunoassays was developed and applied to the Sonogashira reaction. This new method is amenable to coupling reactions and allows the screening of more than 1
An efficient nanocluster catalyst for Sonogashira reaction
Chen, Cheng,Chen, Li,Li, Man-Bo,Luo, Gen,Lv, Qi-Long,Wu, Zhikun,Xu, Guo-Yong,Yang, Jinlong,Yang, Ying,Ye, Sun-Feng,Yuan, Jinyun
, p. 206 - 213 (2021/08/16)
Pd together with CuI has been well known as the catalyst towards Sonogashira reaction, which provides an effective route to functional alkynes. However, the achievement of high activity and selectivity of this catalytic system is still challenging in some cases. Illustrative examples include their low activity for aryl chloride substrates, and switched selectivity to oxidative coupling products in air atmosphere. In this work, a Cu-incorporated Au13 nanocluster [Au13Cu2(PPh3)6(SC2H4Ph)6]+[NO3]- (Au13Cu2) was designed and prepared in high yield via rapid synthesis. This atomically precise nanocluster shows the potential to be a novel catalytic system for Sonogashira reaction, featuring high activity and selectivity, as well as good recyclability even in air atmosphere.
Pyrazine- and pyridine-substituted prop-2-yn-1-ols, but-3-yn-2-ols, and but-3-yn-2-ones –purification, stability, and handling revised
Schindler, Claudia,Schulzke, Carola
, p. 1008 - 1013 (2016/08/26)
A short series of alkynyl-substituted pyrazine and pyridine derivatives was synthesized by the palladium-catalyzed Sonogashira cross-coupling reactions between aryl halides and alkynes. All the products are either white solids or colorless liquids, which is partly in contrast to previous reports. After purification, a color change or intense darkening was observed, in some cases starting almost immediately. Both, the nature of the heteroaromatic ring and the substituents of the alkyne moiety affect their stability. Herein details of synthesis, characterization, and, most importantly, purification and handling are reported.