114977-57-0Relevant articles and documents
Resolution of alkyl pyridyl sulfoxides by complexation with a chiral host compound derived from tartaric acid
Zhu, Jin,Qin, Yong,He, Ze,Fu, Fang-Min,Zhou, Zhong-Yuan,Deng, Jin-Gen,Jiang, Yao-Zhong,Chau, Tay-Yuan
, p. 2505 - 2508 (1997)
Alkyl pyridyl sulfoxides 2 were prepared in high enantiomeric excess by resolution through inclusion complexation with a chiral host compound, (2R,3R) or (2S,3S)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane 1. The X-ray crystallographic structure analysis of complex (R,R)-(-)-1 and (R)-(-)-2b is reported.
Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide
Yang, Jinchuang,Wang, Lianyue,Lv, Ying,Li, Ning,An, Yue,Gao, Shuang
supporting information, p. 156 - 159 (2017/12/15)
We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.
Enantioselective sulfoxidation reaction catalyzed by a G-quadruplex DNA metalloenzyme
Cheng, Mingpan,Li, Yinghao,Zhou, Jun,Jia, Guoqing,Lu, Sheng-Mei,Yang, Yan,Li, Can
, p. 9644 - 9647 (2016/08/04)
Enantioselective sulfoxidation reaction is achieved for the first time by a DNA metalloenzyme assembled with the human telomeric G-quadruplex DNA and Cu(ii)-4,4′-bimethyl-2,2′-bipyridine complex, and the mixed G-quadruplex architectures are responsible for the catalytic enantioselectivity and activity.
