115923-92-7 Usage
Molecular Structure
A derivative of uracil with a 5-fluoro, 6-hydroxy, and 4-amino group.
Function
Antineoplastic agent used in the pharmaceutical industry.
Mechanism
Interferes with the DNA and RNA synthesis of cancer cells, leading to their destruction.
Cancer Treatments
Used in the treatment of various types of cancer, including breast, colon, and bladder cancer.
Administration
Typically administered as a part of combination therapy with other chemotherapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 115923-92-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,2 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115923-92:
(8*1)+(7*1)+(6*5)+(5*9)+(4*2)+(3*3)+(2*9)+(1*2)=127
127 % 10 = 7
So 115923-92-7 is a valid CAS Registry Number.
115923-92-7Relevant articles and documents
Glorination of Pyrimidines. Part 2. Mechanistic Aspects of the Reaction of Acetyl Hypofluorite with Uracil and Cytosine Derivatives
Visser, W. M. Gerard,Herder, E. Renella,Kanter, Frans J. J. de,Herscheid D. M. Jacobus
, p. 1203 - 1208 (2007/10/02)
The reaction of acetyl hypofluorite (AcOF) with uracil, cytosine, and some N-1-substituted derivatives dissolved in either acetic acid or water has been investigated.Analysis by radio-h.p.l.c., using (18)f as a tracer, and by (1)H n.m.r. revealed that a substituent at N-1 of uracil has a remarkable effect on the stability of the intermediate 6-acetoxy-5-fluoro-5,6-dihydrouracils.In addition, it was found that these cytosine adducts rapidly deaminate in water yielding their corresponding uracil analogues.
