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1162-56-7

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1162-56-7 Usage

Uses

Different sources of media describe the Uses of 1162-56-7 differently. You can refer to the following data:
1. 6-Dehydroprogesterone is an impurity found in progesterone.
2. 6-Dehydroprogesterone is an impurity found in progesterone (P755900).

Check Digit Verification of cas no

The CAS Registry Mumber 1162-56-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,6 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1162-56:
(6*1)+(5*1)+(4*6)+(3*2)+(2*5)+(1*6)=57
57 % 10 = 7
So 1162-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

1162-56-7 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001006)  Dydrogesterone impurity B  European Pharmacopoeia (EP) Reference Standard

  • 1162-56-7

  • Y0001006

  • 1,880.19CNY

  • Detail

1162-56-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Pregna-4,6-diene-3,20-dione

1.2 Other means of identification

Product number -
Other names Dydrogesterone impurity B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1162-56-7 SDS

1162-56-7Relevant articles and documents

Synthesis of novel 7α-thiol-bridged progesterone derivatives

Wynne, James H.,Lloyd, Christopher T.,Mushrush, George W.

, p. 885 - 893 (2003)

Novel synthetic routes to the formation of progesterone derivatives are of interest due to their potential role in the treatment of breast cancer. This multi-step synthesis proceeds via the dehydrogenation of the endocyclic ketone moiety of the steroid, a

-

Meystre,Wettstein

, p. 408 (1946)

-

-

McAleer et al.

, p. 958 (1958)

-

Synthesis of 21-diazoprogesterone-6,7-3H2

Chiu,Wolff

, p. 397 - 405 (1979)

The preparation of 21-diazoprogesterone-6,7-3H2 is described. Progesterone was dehydrogenated with chloranil to give Δ6-dehydroprogesterone. Degradation of the pregnane side-chain with sodium hypobromite gave the corresponding carboxylic acid. Catalytic reduction with carrier-free tritium followed by treatment with oxalyl chloride and then diazomethane afforded 21-diazoprogesterone-6,7-3H2 with a specific activity of 42 Ci/mmol.

Method for synthesizing dydrogesterone

-

, (2021/05/19)

The invention relates to a method for synthesizing a steroid drug dydrogesterone (CAS: 152-62-5). The method comprises the following steps: starting from pregnenolone, carrying out allylic halogenation and elimination to obtain a Pregna-5, 7-dien-3-ol-20-one intermediate; carrying out illumination isomerization to obtain a key intermediate 9 beta, 10 alpha-Pregna-5, 7-dien-3-ol-20-one; then carrying out Oppenauer oxidation (Oppenauer oxidation) to obtain 7-Dehydro-9beta, 10 alpha-progesterone, and finally, carrying out olefin shift isomerization under the action of acid to obtain the final product 6-Dehydro-9beta, 10 alpha-progesterone (a crude drug of dydrogesterone). The method is economical in steps and comprises four conversion steps; the total yield is as high as 16.4%; the raw materials are cheap and easy to obtain, the whole process route is green and safe, the bulk drugs are high in quality, the purity can reach 99.5% or above, and the method is suitable for industrial production.

Preparation method for 5,7-pregnadien-3,20-dion-diethylene glycol ketal

-

Page/Page column 7-9, (2020/03/06)

The invention provides a preparation method for 5,7-pregnadien-3,20-dion-diethylene glycol ketal. The method comprises the following steps: performing an etherification reaction on progesterone and anetherification agent under the action of a catalyst to generate an ether; performing a dehydrogenation reaction on the ether and a dehydrogenation reagent to generate 6-dehydroprogesterone; and performing ketalation on the 6-dehydroprogesterone and ethylene glycol under the action of a catalyst and a dehydrating agent to generate the 5,7-pregnadien-3,20-dion-diethylene glycol ketal. The 5,7-pregnadien-3,20-dion-diethylene glycol ketal with less impurities can be obtained through the etherification, dehydrogenation reaction and ketalation, and the method has the advantages of a short route, ahigh yield, low raw material costs, simple operation and environmental protection, and is suitable for industrial production.

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