117-02-2Relevant articles and documents
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Mitter
, (1928)
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Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances
Li, Yuying,Guo, Fang,Chen, Tinggui,Zhang, Liwei,Wang, Zhuanhua,Su, Qiang,Feng, Liheng
, (2020)
The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized, among which 1,3-dihydroxy-6,8-dimethoxyanthracene-9,10-dione is a natural compound that has been synthesized for the very first time, and 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione is a compound that has never been reported earlier. Interestingly, while total seven of these compounds showed neuraminidase inhibitory activity in influenza virus with inhibition rate more than 50 %, specific four compounds exhibited significant inhibition of tumor cell proliferation. The further results demonstrate that 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione showed the best anticancer activity among all the synthesized compounds by inducing highest apoptosis rate to HCT116 cancer cells and arresting their G0/G1 cell cycle phase, through elevation of intracellular level of reactive oxygen species (ROS). Moreover, the binding of 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione with BSA protein has thoroughly been investigated. Altogether, this study suggests the neuraminidase inhibitory activity and antitumor potential of the new emodin anthraquinone derivatives.
Method for synthesizing 2,6-dihydroxytoluene by using waste acid
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, (2021/08/07)
The invention discloses a method for synthesizing 2,6-dihydroxytoluene by using waste acid mechanically. According to the method, 3-chloro-2-methylaniline is taken as a raw material, an intermediate 3-chloro-2-methylphenol is synthesized through diazotization and hydrolysis, the reaction is optimized in the alkali fusion, acidification and refining processes, the mechanical application of waste acid and a solvent in the reaction and the optimization of a refining scheme are emphatically optimized, the yield is effectively improved, three wastes are reduced, and 2,6-dihydroxytoluene is synthesized. The method provided by the invention greatly reduces the generation of acidic wastewater, better meets the requirement of environmental protection, and effectively increases the yield of the product, and the quality of the product reaches 99.0-99.5%.
