117354-64-0 Usage
Uses
2-Hydroxysaclofen is a GABA-B receptor antagonist in the ventral tegmental area and may play a role in the mechanisms of cocaine usage. Affects specific acute nicotine responses in mice, abolishing hypolocomotion and increasing antinociception.
Biological Activity
Selective antagonist at GABA B receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 117354-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,5 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117354-64:
(8*1)+(7*1)+(6*7)+(5*3)+(4*5)+(3*4)+(2*6)+(1*4)=120
120 % 10 = 0
So 117354-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)/t9-/m1/s1
117354-64-0Relevant articles and documents
The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen
Prager, Rolf H.,Schafer, Karl,Hamon, David P. G.,Massy-Westropp, Ralph A.
, p. 11465 - 11472 (2007/10/02)
2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.
Synthesis of 3-Amino-2-(4-chlorophenyl)propanesulfonic Acid (Saclofen) and 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic Acid (Hydroxysaclofen)
Abbenante, Giovanni,Prager, Rolf H.
, p. 213 - 214 (2007/10/02)
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