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118-70-7

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118-70-7 Usage

General Description

4,5,6-Triaminopyrimidine is a chemical compound with the formula C4H7N7. It is a tri-substituted pyrimidine derivative that consists of a pyrimidine core with three amino substituents at the 4, 5, and 6 positions. It is primarily used in pharmaceutical research as a building block for the synthesis of various bioactive molecules, including antiviral and anticancer agents. Additionally, it has been studied for its potential as a corrosion inhibitor in industrial applications. 4,5,6-Triaminopyrimidine has also been investigated for its use in organic synthesis and as a starting material for the preparation of heterocyclic compounds with biological activity.

Check Digit Verification of cas no

The CAS Registry Mumber 118-70-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 8 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 118-70:
(5*1)+(4*1)+(3*8)+(2*7)+(1*0)=47
47 % 10 = 7
So 118-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N5.H2O4S.H2O/c5-2-3(6)8-1-9-4(2)7;1-5(2,3)4;/h1H,5H2,(H4,6,7,8,9);(H2,1,2,3,4);1H2

118-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,5,6-Triaminopyrimidine

1.2 Other means of identification

Product number -
Other names Pyrimidine-4,5,6-triamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118-70-7 SDS

118-70-7Relevant articles and documents

A synthesis of adenine. The incorporation of isotopes of nitrogen and carbon

Cavalieri, Liebe F.,Tinker, John F.,Bendich, Aaron.

, p. 533 - 536 (1949)

Various synthests of adenine have been investigated and a satisfactory procedure for the introduction of isotopes of nitrogen and carbon has been developed. 'The preparation from isotopic carbon of cyanoacetamide and malononitrile is described.

Synthesis method of 4,5,6-triaminopyrimidine

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Paragraph 0022; 0026-0027; 0031-0032; 0036-0037; 0041, (2019/11/14)

The invention discloses a synthesis method of 4,5,6-triaminopyrimidine. The synthesis method includes the following steps that an intermediate product of 4,6-dichloro-5-nitropyrimidine is prepared by5-nitro-4,6-dihydroxypyrimidine, phosphorus oxychloride and organic alkali; ethyl alcohol is added into a product prepared by the 4,6-dichloro-5-nitropyrimidine and ammonium hydroxide to obtain a product; and the 4,5,6-triaminopyrimidine is prepared by the product, hydrazine hydrate, and raney nickel. According to the synthesis method, targeted objects can be obtained just through three steps, total yield is high, synthesis routes are short, reaction is mild, time is short, operation is easy and safe, at the same time, the 4,6-dichloro-5-nitropyrimidine is taken as a starting material, due tothe fact that the starting material has a large amount of commercial supplies, and is cheap and easy to obtain, an auxiliary material can be recycled and reused, and the cost can be significantly reduced; and due to the fact that appropriate raw material and auxiliary material are selected, the pollution of toxic substances to environments in the production process is avoided, the yield and purityof prepared pyrimidine are high, and the pyrimidine has good industrial application prospects.

Adenine intermediate pyrimidine-azo compound and preparation method thereof

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Paragraph 0029, (2017/07/14)

The invention relates to an adenine intermediate pyrimidine-azo compound and a preparation method thereof. The preparation method comprises the following steps of: 1) dissolving primary amine in mixed-acid solution, dripping sodium nitrite solution to prepare diazonium salt shown in a formula (3), adding malononitrile for dissolving, and dripping alkaline solution to regulate a pH value of reaction solution and generate coupling reaction, thereby obtaining an intermediate pyrimidine-azo compound (4); 2) adding the intermediate pyrimidine-azo compound (4) prepared in the step 1) into formamide, introducing liquid ammonia, and heating to carry out high-temperature condensation and cyclization reaction, thereby obtaining an adenine intermediate pyrimidine-azo compound (5), wherein a series of derivatives of the adenine intermediate pyrimidine-azo compound can be prepared by selecting different primary amines. The adenine intermediate pyrimidine-azo compound and the preparation method have the advantages that water is used as a solvent in the step 1), and the solvent used in the step 2) can be repeatedly used, so that the 'three wastes' are fewer, and the environment-friendly effect is achieved; and the cost is low, so that the industrialization is easy and the economic benefit is obvious.

Synthesis of carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives as new potential PET tracers for imaging of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)

Gao, Mingzhang,Wang, Min,Zheng, Qi-Huang

, p. 1371 - 1375 (2016/02/19)

The target tracer carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives, N-(3-[11C]methoxy-4-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (3-[11C]4a) and N-(4-[11C]methoxy-3-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (4-[11C]4a); 2-((6-amino-9H-purin-8-yl)thio)-N-(3-[11C]methoxy-4-methoxyphenyl)acetamide (3-[11C]8a) and 2-((6-amino-9H-purin-8-yl)thio)-N-(4-[11C]methoxy-3-methoxyphenyl)acetamide (4-[11C]8a), were prepared by O-[11C]methylation of their corresponding precursors with [11C]CH3OTf under basic condition (2 N NaOH) and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 23 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 185-555 GBq/μmol.

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