118026-14-5Relevant articles and documents
Preparation method of zolpidem
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Paragraph 0017; 0028; 0034-0035, (2021/08/19)
The invention discloses a preparation method of a zolpidem intermediate. In the process of preparing the zolpidem intermediate N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride by reducing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride, through process optimization and parameter adjustment, by using a 10% palladium-carbon catalyst and combining the reaction condition of hydrogen pressure of 0.02-0.09 MPa, the conversion effect of the N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-chloroacetamide hydrochloride is promoted, side reactions and impurities are reduced, the product yield is increased, the problem of low product synthesis yield in the process of preparing N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo [1, 2-alpha] pyridine-3-acetamide hydrochloride through reduction reaction in zolpidem production is solved, and the production cost of zolpidem tartrate is reduced.
Preparation method of zolpidem impurities
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Paragraph 0044-0047, (2020/04/17)
The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of zolpidem impurities. The method is a brand-new zolpidem impurity preparation method. According to the method, a compound II (N, N, 6-trimethyl-2-(4-methylphenyl)-imidazo[1, 2-alpha]pyridin-3-alpha-hydroxyacetamide) is used as a raw material and is combined with a specific polyphosphoric acid, concentrated sulfuric acid and aluminum trichloride acid catalysis system, and the mixture undergoes a reaction at the temperature of 80-140 DEG C. The product yield is high, the operation is simple, the method is suitable for the large-scale industrial production of the zolpidem impurity compound I, and the impurity detection monitoring during the zolpidem synthesis process is easily achieved.
