118419-93-5Relevant articles and documents
Asymmetric synthesis of a selective endothelin a receptor antagonist
Kato, Yoshiaki,Niiyama, Kenji,Jona, Hideki,Okada, Shigemitsu,Akao, Atsushi,Hiraga, Shouichi,Tsuchiya, Yoshimi,Tomimoto, Koji,Mase, Toshiaki
, p. 1066 - 1072 (2007/10/03)
An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. Asymmetric conjugate addition of aryllithium derived from 18 to the chiral oxazoline 17 followed by hydrolysis afforded 15 in 96% ee via purification as (S)-(-)-1-phe
Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances
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, (2008/06/13)
Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula (I): in which, Y = NH, O or S when m = 1;, Y = N when m = 2;, m = 1 or 2;, l = 0 or 4;, R = H, C1 4 alkyl, Cl, Br, CF3, CH2OCOCH3, or OCH2-Ph;, R1 = H, alkaline metal or alkaline earth metal;, the double bond of the alkenyl chain being of trans or cis configuration and the possible benzene ring being unsubstituted or substituted. Said derivatives possess high antiallergic activity.