118460-46-1Relevant articles and documents
A facile P-C bond cleavage of 2-fluoro2-phosphonyl-1,3-dicarbonyl compounds on silica gel
Kim, Dae Young
, p. 1205 - 1212 (2000)
α-Fluoro-β-keto esters and α-fluoromalonates were prepared by the P-C bond cleavage of 2-fluoro-2-phosphonyl-1,3-dicarbonyl compounds on wet silica gel.
P-C bond cleavage of triethyl 2-fluoro-3-oxo-2-phosphonoacetates with magnesium chloride: A synthesis of α-fluoro-β-keto esters
Kim, Dae Young,Choi, Jin Seok,Rhie, Dae Yong
, p. 1097 - 1103 (1997)
P-C bond cleavage of triethyl 2-fluoro-3-oxo-2-phosphonoacetates in the presence of magnesium chloride provides a synthetic route to α-fluoro-β-keto esters.
Nucleophilic fluorination of β-ketoester derivatives with HBF 4
Pasceri, Raffaele,Bartrum, Hannah E.,Hayes, Christopher J.,Moody, Christopher J.
supporting information, p. 12077 - 12079 (2013/01/16)
Treating readily available α-diazo-β-ketoesters with HBF 4 results in nucleophilic fluorination by the usually inert and stable tetrafluoroborate anion. The resulting α-fluoro-β-ketoesters are highly versatile synthetic intermediates, for example in the preparation of fluoro-heterocycles, as illustrated by the direct formation of fluoro-pyrimidines, -pyrazoles and -coumarins in a single step.
