118507-50-9Relevant articles and documents
Diphenylsilane as a coupling reagent for amide bond formation
Sayes, Morgane,Charette, André B.
supporting information, p. 5060 - 5064 (2017/11/09)
A simple procedure for amide bond formation using diphenylsilane as a coupling reagent is described. This methodology enables the direct coupling of carboxylic acids with primary and secondary amines, releasing only hydrogen and a siloxane as by-products. Only one equivalent of each partner is needed, providing a more sustainable amidation method producing minimal wastes. This methodology was also extended to the synthesis of peptides and lactams by addition of Hünig's base (DIPEA) and 4-dimethylaminopyridine (DMAP).
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
Abe, Masatoshi,Akiyama, Tetsuo,Umezawa, Yoji,Yamamoto, Keiichiro,Nagai, Masashi,Yamazaki, Hiroko,Ichikawa, Yuh-Ichiro,Muraoka, Yasuhiko
, p. 785 - 797 (2007/10/03)
The structure of sulphostin (1), a novel dipeptidyl peptidase IV (DPP-IV) inhibitor, is consisted of three key functional groups, including a characteristic amino(sulfoamino)phosphinyl group, on a piperidine ring. To examine the relationship between its s
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
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Page/Page column 41, (2008/06/13)
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.