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118724-05-3

118724-05-3

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118724-05-3 Usage

Uses

1H-[1,2,3]Triazol-4-ylmethylamine HCl is used in the preparation of optimized 5-membered heterocycle-linked pterins for inhibition of ricin toxin A. Also used in the synthesis of orally bioavailiable human neurokinin-1 (hNK1) antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 118724-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,7,2 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 118724-05:
(8*1)+(7*1)+(6*8)+(5*7)+(4*2)+(3*4)+(2*0)+(1*5)=123
123 % 10 = 3
So 118724-05-3 is a valid CAS Registry Number.
InChI:InChI=1/C3H6N4/c4-1-3-2-5-7-6-3/h2H,1,4H2,(H,5,6,7)

118724-05-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-[1,2,3]Triazol-4-Ylmethylamine Hcl

1.2 Other means of identification

Product number -
Other names 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118724-05-3 SDS

118724-05-3Downstream Products

118724-05-3Relevant articles and documents

1,3-Dipolar cycloadditions of MeOPEG-bounded azides

Molteni, Giorgio,Del Buttero, Paola

, p. 4983 - 4987 (2005)

1,3-Dipolar cycloadditions of MeOPEG-supported azide 2 with a variety of dipolarophiles have been studied. 1-MeOPEG-supported 1,2,3-triazoles 4 and 5, 1,2,3,4-tetrazoles 12 and aziridine 14 were obtained in nearly quantitative yields. The removal of the MeOPEG moiety from the 1,2,3-triazole nucleus was achieved by acidic cleavage of the cycloadduct mixtures 4 and 5 giving 4- and 5-substituted-1,2,3-triazoles 6 and 7.

Reactions of Unsaturated Azides, 6 Synthesis of 1,2,3-Triazoles from Propargyl Azides by Rearrangement of the Azido Group. - Indication of Short-Lived Allenyl Azides and Triazafulvenes

Banert, Klaus

, p. 911 - 918 (2007/10/02)

Treatment of 3-bromo-3-methyl-1-butyne (1) or 1-iodo-3-methyl-1,2-butadiene (3) with solutions of sodium azide affords 3-azido-3-methyl-1-butyne (5) which reacts already at room temperature to 1,2,3-triazoles 8-11.Structures of 5 and 8-11 are verified by independent syntheses and spectroscopic data although in part other assignments of structures have been published.The preparation of 1H-1,2,3-triazoles via propargyl azides is carried out in the presence of various nucleophiles and investigated by means of 15N-labelled starting material as well as optically active 3-azido-1-butyne (R-21).The only mechanism compatible with all results includes short-lived allenyl azides and triazafulvenes.Thus, propargyl azide 14 rearranges to allenyl azide 16 leading to triazafulvene 18 by rapid ring closure.Finally, 18 is trapped by nucleophiles to give triazole 17.The conversion of various propargyl compounds into N-unsubstituted 1H-1,2,3-triazoles 23, 41, 44, 46, 50, and 51 is effected by a one-pot procedure without isolation of 14 and turns out to be a convenient method to prepare these heterocycles. - Key Words: Allenyl azides, ring closure of / Propargyl azides, rearrangement of / Triazafulvenes, nucleophilic addition to / Triazoles, preparation of

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