1188-35-8Relevant articles and documents
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Shchegolev,A.A.,Kucherov,V.F.
, (1972)
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CONTRAST AGENTS
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Page/Page column 58, (2008/06/13)
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
PROSTANOIDS. VII. trans-2,3-DIETHOXYCARBONYLCYCLOPENTANONE IN THE SYNTHESIS OF PROSTAGLANDINS
Tolstikov, G. A.,Miftakhov, M. S.,Akbutina, F. A.
, p. 268 - 277 (2007/10/02)
2,3-Diethoxycarbonylcyclopentanone was synthesized from methyl 3-cyclohexenecarboxylate; its telomerization with 1,3-butadiene gave 2-(2,7-octadienyl)2,3-diethoxycarbonylcyclopentanone, which was then transformed into 2α-(2,7-octadienyl)-3β-(3α-hydroxy-1-trans-octenyl)-1α-cyclopentanol, i.e., an analog of 11-deoxyprostaglandin-F1α.The key synthon for the synthesis of 11-deoxy-α-homoprostaglandin-E1 was obtained from 2-(2,7-octadienyl)-3-ethoxycarbonylcyclopentanone.A new method was developed for the production of the γ-lactone of 5α-hydroxy-2β-(3-oxo-1-trans-octenyl)-1α-cyclopentaneacetic acid - a well-known synthon in the synthesis of 11-deoxyprostaglandin-E2.The method was based on the alkylation of 2,3-diethoxycarbonylcyclopentanone with allyl bromide.
